지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 665 - 673 (9page)
이용수
초록· 키워드
오류제보하기
After invasion of red blood cells, malaria matures within the cell by degrading hemoglobin avidly. For enormous protein breakdown in trophozoite stage, many efficient and ordered proteolysis networks have been postulated and exploited. In this study, a potential interaction of a 60-kDa Plasmodium falciparum (Pf)-heat shock protein (Hsp60) and Pf-calpain, a cysteine protease, was explored. Pf-infected RBC was isolated and the endogenous Pf-Hsp60 and Pf-calpain were determined by western blot analysis and similar antigenicity of GroEL and Pf-Hsp60 was determined with anti-Pf-Hsp60. Potential interaction of Pf-calpain and Pf-Hsp60 was determined by immunoprecipitation and immunofluorescence assay. Mizoribine, a well-known inhibitor of Hsp60, attenuated both Pf-calpain enzyme activity as well as P. falciparum growth. The presented data suggest that the Pf-Hsp60 may function on Pf-calpain in a part of networks during malaria growth.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
[인터넷자원] - / / World Malaria Report
[학술지(정기간행물)] - Pallavi R / 2010 / Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of hsp90 from plasmodium falciparum and trypanosoma evansi and evaluation of its inhibitor as a candidate drug / J Biol Chem 285 : 37964 ~ 37975
[학술지(정기간행물)] - Acharya P / 2007 / Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum / Mol Biochem Parasitol 153 : 85 ~ 94
[학술지(정기간행물)] - Pavithra SR / 2007 / Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum / PLoS Comput Biol 3 : 1701 ~ 1715
[학술지(정기간행물)] - Rug M / 2011 / The heat shock protein 40 family of the malaria parasite Plasmodium falciparum / IUBMB Life 63 : 1081 ~ 1086
[학술지(정기간행물)] - Pallavi R / 2010 / Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of hsp90 from plasmodium falciparum and trypanosoma evansi and evaluation of its inhibitor as a candidate drug / J Biol Chem 285 : 37964 ~ 37975
[학술지(정기간행물)] - Acharya P / 2007 / Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum / Mol Biochem Parasitol 153 : 85 ~ 94
[학술지(정기간행물)] - Pavithra SR / 2007 / Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum / PLoS Comput Biol 3 : 1701 ~ 1715
[학술지(정기간행물)] - Rug M / 2011 / The heat shock protein 40 family of the malaria parasite Plasmodium falciparum / IUBMB Life 63 : 1081 ~ 1086
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UCI(KEPA) : I410-ECN-0101-2016-513-002211704