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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 26 - 32 (7page)
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BACKGROUND/OBJECTIVES: It has been shown that vitamin A supplementation has different effects on skeletal health and the antioxidant system. Deficiency or excess of this vitamin can lead to health problems. Vitamin A can work as either an antioxidant or prooxidant depending on its concentration. The present study was conducted to investigate the effects of different doses of vitamin A supplementation on the antioxidant system in rats.
MATERIALS/METHODS: Forty Spargue-Dawley male rats were divided into four groups according to the dose of vitamin A received: 0 (A0), 4,000 (A1), 8,000 (A2), and 20,000 (A3) IU retinyl palmitate/kg diet. After a feeding period of 4 wks, lipid peroxide levels, glutathione concentration, antioxidant enzyme activities, and vitamins A and E concentrations were measured. Histopathological changes were observed in rat liver tissue using an optical microscope and transmission electron microscope.
RESULTS: Lipid peroxide levels in plasma were significantly decreased in the A1 and A2 groups compared to the A0 rats. Erythrocyte catalase and hepatic superoxide dismutase activities of the A2 group were significantly higher than those of the A0 group. Hepatic glutathione peroxidase activity was significantly lower in the A3 group compared to the other groups. Total glutathione concentrations were significantly higher in the A1 and A2 groups than in the A0 group. Histological examination of liver tissue showed that excessive supplementation of vitamin A might lead to lipid droplet accumulation and nuclear membrane deformation.
CONCLUSIONS: These results indicate that appropriate supplementation of vitamin A might have a beneficial effect on the antioxidant system in rats.
MATERIALS/METHODS: Forty Spargue-Dawley male rats were divided into four groups according to the dose of vitamin A received: 0 (A0), 4,000 (A1), 8,000 (A2), and 20,000 (A3) IU retinyl palmitate/kg diet. After a feeding period of 4 wks, lipid peroxide levels, glutathione concentration, antioxidant enzyme activities, and vitamins A and E concentrations were measured. Histopathological changes were observed in rat liver tissue using an optical microscope and transmission electron microscope.
RESULTS: Lipid peroxide levels in plasma were significantly decreased in the A1 and A2 groups compared to the A0 rats. Erythrocyte catalase and hepatic superoxide dismutase activities of the A2 group were significantly higher than those of the A0 group. Hepatic glutathione peroxidase activity was significantly lower in the A3 group compared to the other groups. Total glutathione concentrations were significantly higher in the A1 and A2 groups than in the A0 group. Histological examination of liver tissue showed that excessive supplementation of vitamin A might lead to lipid droplet accumulation and nuclear membrane deformation.
CONCLUSIONS: These results indicate that appropriate supplementation of vitamin A might have a beneficial effect on the antioxidant system in rats.
목차
INTRODUCTION4
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
Lee MJ, Kim JH. The changes of dietary reference intakes for Koreans and its application to the new text book. J Korean Home Econ Educ Assoc 2008;20:75-94.
The Korean Nutrition Society. Dietary Reference Intakes for Koreans. 1st rev. ed. Seoul: The Korean Nutrition Society; 2010.
Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V-1). Cheongwon; Korea Centers for Disease Control and Prevention: 2011.
Demissie T, Haider J, Tibeb HN, Haile B. Impact evaluation of EPI-PLUS and WIBS approaches in controlling vitamin A deficiency in Tigray and Harari regions, Ethiopia. Ethiop J Health Dev 2000;14: 303-10.
Oliveros L, Vega V, Anzulovich AC, Ramirez D, Giménez MS. Vitamin A deficiency modifies antioxidant defenses and essential element contents in rat heart. Nutr Res 2000;20:1139-50.
The Korean Nutrition Society. Dietary Reference Intakes for Koreans. 1st rev. ed. Seoul: The Korean Nutrition Society; 2010.
Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V-1). Cheongwon; Korea Centers for Disease Control and Prevention: 2011.
Demissie T, Haider J, Tibeb HN, Haile B. Impact evaluation of EPI-PLUS and WIBS approaches in controlling vitamin A deficiency in Tigray and Harari regions, Ethiopia. Ethiop J Health Dev 2000;14: 303-10.
Oliveros L, Vega V, Anzulovich AC, Ramirez D, Giménez MS. Vitamin A deficiency modifies antioxidant defenses and essential element contents in rat heart. Nutr Res 2000;20:1139-50.
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UCI(KEPA) : I410-ECN-0101-2016-594-002431725