This study was done to measure the level of social support, self-esteem, and empowerment and to identify any effect of social support and self-esteem on the empowerment of nurses. Methods: The study design was a descriptive survey using questionnaires which were given to 381 nurses in C province. The collected data were analyzed using descriptive analysis, t-test, ANOVA, Pearson correlation coefficient, and multiple regressions. Results: The mean score for nurses’ empowerment was 2.83±0.66. Seven individual characteristics, social support(family, meaningful persons, supervisors, and co-workers) and self-esteem accounted for 23.3% of the variance in nurses’ empowerment. Prediction elements influencing empowerment of nurses were salary per month, self-esteem, and social support(supervisors). Conclusion: The results indicate that it is necessary to increase nurses’ empowerment. Social support by supervisors and self-esteem were confirmed as important factors to increase nurses’ empowerment. In addition, raising the monthly average income would increase empowerment of nurses.