지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.90 No.5
- 발행연도
- 2016.5
- 수록면
- 250 - 256 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Depth of wall invasion is an important prognostic factor in patients with gastric cancer, whereas the prognostic significance of intraoperative macroscopic serosal invasion (mSE) findings remain unclear when they show a discrepancy in pathologic findings. This study, therefore, assessed the prognostic significance of mSE.
Methods: Data from cohort of 2,835 patients with resectable gastric cancer who underwent surgery between 1990 and 2010 were retrospectively reviewed.
Results: The overall accuracy of mSE and pathologic results was 83.4%. The accuracy of mSE was 75.5% in pT2. On the other hand, the accuracy of pT3 dropped to 24.5%. According to mSE findings (+/–), the 5-year disease-specific survival (DSS) rate differed significantly in patients with pT2 (+; 74.2% vs. –; 92.0%), pT3 (+; 76.7% vs. –; 91.8%) and pT4a (+; 51.3% vs. –; 72.8%) (P < 0.001 each), but not in patients with T1 tumor. Multivariate analysis showed that mSE findings (hazard ratio [HR], 2.275; 95% confidence interval [CI], 1.148–4.509), tumor depth (HR, 6.894; 95% CI, 2.325–20.437), nodal status (HR, 5.206; 95% CI, 2.298–11.791), distant metastasis (HR, 2.881; 95% CI, 1.388–6.209), radical resection (HR, 2.002; 95% CI, 1.017–3.940), and lymphatic invasion (HR, 2.713; 95% CI, 1.424–5.167) were independent predictors of 5-year DSS rate.
Conclusion: We observed considerable discrepancies between macroscopic and pathologic diagnosis of serosal invasion. However, macroscopic diagnosis of serosal invasion was independently prognostic of 5-year DSS. It suggests that because the pathologic results could not be perfect and the local inflammatory change with mSE(+) could affect survival, a combination of mSE(+/–) and pathologic depth may be predictive of prognosis in patients with gastric cancer.
Methods: Data from cohort of 2,835 patients with resectable gastric cancer who underwent surgery between 1990 and 2010 were retrospectively reviewed.
Results: The overall accuracy of mSE and pathologic results was 83.4%. The accuracy of mSE was 75.5% in pT2. On the other hand, the accuracy of pT3 dropped to 24.5%. According to mSE findings (+/–), the 5-year disease-specific survival (DSS) rate differed significantly in patients with pT2 (+; 74.2% vs. –; 92.0%), pT3 (+; 76.7% vs. –; 91.8%) and pT4a (+; 51.3% vs. –; 72.8%) (P < 0.001 each), but not in patients with T1 tumor. Multivariate analysis showed that mSE findings (hazard ratio [HR], 2.275; 95% confidence interval [CI], 1.148–4.509), tumor depth (HR, 6.894; 95% CI, 2.325–20.437), nodal status (HR, 5.206; 95% CI, 2.298–11.791), distant metastasis (HR, 2.881; 95% CI, 1.388–6.209), radical resection (HR, 2.002; 95% CI, 1.017–3.940), and lymphatic invasion (HR, 2.713; 95% CI, 1.424–5.167) were independent predictors of 5-year DSS rate.
Conclusion: We observed considerable discrepancies between macroscopic and pathologic diagnosis of serosal invasion. However, macroscopic diagnosis of serosal invasion was independently prognostic of 5-year DSS. It suggests that because the pathologic results could not be perfect and the local inflammatory change with mSE(+) could affect survival, a combination of mSE(+/–) and pathologic depth may be predictive of prognosis in patients with gastric cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Takagane A, Terashima M, Abe K, Araya
M, Irinoda T, Yonezawa H, et al. Evaluation
of the ratio of lymph node metastasis
as a prognostic factor in patients with
gastric cancer. Gastric Cancer 1999;2:122-
8.
Lindsey H. Preoperative chemoradiotherapy
shows promise in gastric cancer.
Lancet Oncol 2004;5:519.
Shimoyama S, Seto Y, Yasuda H, Mafune
K, Kaminishi M. Concepts, rationale, and
current outcomes of less invasive surgical
strategies for early gastric cancer: data
from a quarter-century of experience in a
single institution. World J Surg 2005;29:
58-65.
Jemal A, Siegel R, Ward E, Hao Y, Xu J,
Thun MJ. Cancer statistics, 2009. CA
Cancer J Clin 2009;59:225-49.
Park do J, Kong SH, Lee HJ, Kim WH,
Yang HK, Lee KU, et al. Subclassification
of pT2 gastric adenocarcinoma according
to depth of invasion (pT2a vs pT2b) and
lymph node status (pN). Surgery 2007;141:
757-63.
Lindsey H. Preoperative chemoradiotherapy
shows promise in gastric cancer.
Lancet Oncol 2004;5:519.
Shimoyama S, Seto Y, Yasuda H, Mafune
K, Kaminishi M. Concepts, rationale, and
current outcomes of less invasive surgical
strategies for early gastric cancer: data
from a quarter-century of experience in a
single institution. World J Surg 2005;29:
58-65.
Jemal A, Siegel R, Ward E, Hao Y, Xu J,
Thun MJ. Cancer statistics, 2009. CA
Cancer J Clin 2009;59:225-49.
Park do J, Kong SH, Lee HJ, Kim WH,
Yang HK, Lee KU, et al. Subclassification
of pT2 gastric adenocarcinoma according
to depth of invasion (pT2a vs pT2b) and
lymph node status (pN). Surgery 2007;141:
757-63.
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UCI(KEPA) : I410-ECN-0101-2016-514-002860660