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논문 기본 정보

자료유형
학술저널
저자정보
Yong Hyun Chung (Korea Occupational Safety and Health Agency) Seo-Ho Shin (Korea Occupational Safety and Health Agency) Jeong Hee Han (Korea Occupational Safety and Health Agency) Yong-Hoon Lee (Korea Occupational Safety and Health Agency)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.32 No.3
발행연도
2016.7
수록면
245 - 250 (6page)

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초록· 키워드

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3-Methylpentane (C<SUB>6</SUB>H<SUB>14</SUB>, CAS No. 96-14-0), isomer of hexane, is a colorless liquid originating naturally from petroleum or natural gas liquids. 3-Methylpentane has been used as a solvent in organic synthesis, as a lubricant, and as a raw material for producing carbon black. There is limited information available on the inhalation toxicity of 3-methylpentane, and the aim of this study was to determine its subacute inhalation toxicity. According to OECD Test Guideline 412 (subacute inhalation toxicity: 28-day study), Sprague Dawley rats were exposed to 0, 284, 1,135, and 4,540 ppm of 3-methylpentane for 6 hr/day, 5 days/week for 4 weeks via whole-body inhalation. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, organ weights, and gross and histopathological findings were compared between control and all exposure groups. No mortality or remarkable clinical signs were observed during the study. No gross or histopathological lesions, or adverse effects on body weight, food consumption, hematology, serum chemistry, and organ weights were observed in any male or female rats in all exposure groups, although some statistically significant changes were observed in food consumption, serum chemistry, and organ weights. In conclusion, the results of this study indicate that no observable adverse effect level (NOAEL) for 3-methylpentane above 4,540 ppm/6 hr/day, 5 days/week for rats.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2017-513-000816789