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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.30
- 발행연도
- 2015.12
- 수록면
- 43 - 49 (7page)
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초록· 키워드
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Objectives: This study aimed to estimate the effects of 4-nonylphenol (NP), a ubiquitously present surfactant in aquatic environments, on the anti-oxidant systems of the liver in the Far Eastern catfish Silurus asotus.
Methods: Changes in biochemical parameters involved in glutathione (GSH)-related and other anti-oxidant systems were analyzed following 4 weeks of 4-NP administration(0.1 and 1.0 mg/kg diet) via a formulated diet to catfish.
Results: 4-NP exposure induced an elevation in hepatic lipid peroxide levels and an accompanying decrease in reduced state GSH after 2 weeks, suggesting pro-oxidant effects of the chemical in catfish. This oxidative stress was associated with an inhibition of the GSH-utilizing enzyme glutathione peroxidase at the same time point. This inhibition was restored after 4 weeks. The activities of other anti-oxidant enzymes, i.e., glutathione reductase, superoxide dismutase and catalase were increased after 4 weeks. These enzyme increases occurred more strongly at the higher 4-NP concentration (1.0 mg/kg diet).
Conclusions: 4-NP given to catfish at 0.1 to 1.0 mg/kg diet, concentrations relevant to environmental levels, depletes the endogenous anti-oxidant molecule GSH and temporarily inhibits GSH-related anti-oxidant enzymes. Such declines in anti-oxidant capacity and elevated oxidative stress seem to be compensated eventually by subsequent activation of various anti-oxidant enzyme systems.
Methods: Changes in biochemical parameters involved in glutathione (GSH)-related and other anti-oxidant systems were analyzed following 4 weeks of 4-NP administration(0.1 and 1.0 mg/kg diet) via a formulated diet to catfish.
Results: 4-NP exposure induced an elevation in hepatic lipid peroxide levels and an accompanying decrease in reduced state GSH after 2 weeks, suggesting pro-oxidant effects of the chemical in catfish. This oxidative stress was associated with an inhibition of the GSH-utilizing enzyme glutathione peroxidase at the same time point. This inhibition was restored after 4 weeks. The activities of other anti-oxidant enzymes, i.e., glutathione reductase, superoxide dismutase and catalase were increased after 4 weeks. These enzyme increases occurred more strongly at the higher 4-NP concentration (1.0 mg/kg diet).
Conclusions: 4-NP given to catfish at 0.1 to 1.0 mg/kg diet, concentrations relevant to environmental levels, depletes the endogenous anti-oxidant molecule GSH and temporarily inhibits GSH-related anti-oxidant enzymes. Such declines in anti-oxidant capacity and elevated oxidative stress seem to be compensated eventually by subsequent activation of various anti-oxidant enzyme systems.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (30)
참고문헌 신청
Soverchia L. / 2005 / Modulation of vitellogenin synthesis through estrogen receptor beta-1 in goldfish(Carassius auratus)juveniles exposed to 17-beta estradiol and nonylphenol / Toxicol Appl Pharmacol 209(3):236~243
Lacorte S. / 2006 / Pilot survey of a broad range of priority pollutants in sediment and fish from the Ebro river basin(NE Spain) / Environ Pollut 140(3):471~482
European Chemicals Agency. / Support document for identification of 4-nonylphenol, branched and linear, ethoxylated
Ahel M. / 1993 / Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms / Environ Pollut 79(3):243~248
Pomatto V. / 2011 / Xenoestrogens elicit a modulation of endocannabinoid system and estrogen receptors in 4NP treated goldfish, Carassius auratus / Gen Comp Endocrinol 174(1):30~35
Lacorte S. / 2006 / Pilot survey of a broad range of priority pollutants in sediment and fish from the Ebro river basin(NE Spain) / Environ Pollut 140(3):471~482
European Chemicals Agency. / Support document for identification of 4-nonylphenol, branched and linear, ethoxylated
Ahel M. / 1993 / Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms / Environ Pollut 79(3):243~248
Pomatto V. / 2011 / Xenoestrogens elicit a modulation of endocannabinoid system and estrogen receptors in 4NP treated goldfish, Carassius auratus / Gen Comp Endocrinol 174(1):30~35
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UCI(KEPA) : I410-ECN-0101-2017-539-000798842