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(Sogang University) (Sogang University) (Yonsei University College of Medicine) (Yonsei University College of Medicine) (Yonsei University College of Medicine) (Sogang University)
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한국미생물학회 한국미생물학회 학술대회논문집 2013년도 International Meeting of the Microbiological Society of Korea
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    Vibrio vulnificus is a causative agent of septicemia by secretion of various virulence factors, one of which is represented by an elastase, VvpE. Zymograhic analysis of the V. vulnificus secretome showed the presence of multiple extracellular proteases in addition to VvpE. One of them is identified as a metalloprotease, VvpM, which contains a Zn-binding motif and an active site for a typical Zn-metalloprotease. Human cells challenged to the recombinant VvpM (rVvpM) showed typical apoptotic-positive phenotypes including morphological changes in nucleus and mitochondria. Furthermore, increased staining by Annexin-V and cleavages of caspases were evidenced in the rVvpM-exposed cells. Expression of ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2017-475-001058686