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(Carnegie Mellon University) (Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center) (Carnegie Mellon University) (Carnegie Mellon University) (Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center) (Carnegie Mellon University)
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한국미생물학회 한국미생물학회 학술대회논문집 2016년도 International Meeting of the Microbiological Society of Korea
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    초록·키워드

    We have analyzed expression of environmentally responsive genes and transcription factor genes to infer signals and pathways that drive pathogen gene regulation during invasive Candida albicans infection of a mammalian host. Both sets of genes reveal both early and late phases of infection. The early phase includes induction of zinc and iron limitation genes, genes that respond to transcription factor Rim101, and genes characteristic of invasive hyphal cells. The late phase includes responses related to phagocytosis by macrophages. Transcription factor genes that are required for virulence or proliferation in vivo are enriched among highly expressed transcription factor genes. Mutants defective in six transcription f ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2017-475-001041614