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CK2 Kinase-dependent Regulation of Stress-responsive Transcription Factors in Saccharomyces cerevisiae

논문 기본 정보

저자정보
(Seoul National University)
저널정보
한국미생물학회 한국미생물학회 학술대회논문집 2015년도 International Meeting of the Microbiological Society of Korea
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41 - 41 (1page)
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CK2 Kinase-dependent Regulation of Stress-responsive Transcription Factors in Saccharomyces cerevisiae
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    초록·키워드

    CK2 is an evolutionarily conserved kinase with a wide range of biological functions. In this study, we elucidated the roles of CK2 in regulation of stress responses and cell growth in Saccharomyces cerevisiae. Heat shock transcription factor (Hsf1) and general stress-responsive transcription factor (Msn2/4) play important roles in cellular defense against various stress conditions such as heat shock, oxidative stress, osmotic stress, and nutrient starvation. Multiple phosphorylations are the major regulatory mechanisms for theses transcription factors. However, it is still elusive how the phosphorylation events integrate multiple stress signals into the differential regulation of HSF and Msn2/4. We demonstrated that CK2-dependent phosphorylation on S608 is an ethanol stress-specific repression mechanism of Hsf1, which is relieved by Ppt1-dependent dephosphorylation. Expression of Hsf1S608A mutant enhanc ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2017-475-001047510