지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 366 - 372 (7page)
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초록· 키워드
오류제보하기
K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17<SUP>–/–</SUP> mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17<SUP>–/– </SUP>mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3– CD4– gdTCR– NK1.1– Sca1<SUP>int</SUP> Thy1<SUP>hi</SUP> cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1<SUP>int</SUP> Thy1<SUP>hi</SUP> cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.
목차
INTRODUCTION
Materials and Methods
Results and Discussion
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Lee, D. M / 2001 / Rheumatoid arthritis / Lancet 358 : 903 ~ 911
[학술지(정기간행물)] - Monach, P. A / 2004 / The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease / Adv. Immunol 82 : 217 ~ 248
[학술지(정기간행물)] - Kouskoff, V / 1996 / Organ-specific disease provoked by systemic autoimmunity / Cell 87 : 811 ~ 822
[학술지(정기간행물)] - Korganow, A. S / 1999 / From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins / Immunity 10 : 451 ~ 461
[학술지(정기간행물)] - Brennan, F. M / 1998 / Role of pro-inflammatory cytokines in rheumatoid arthritis / Springer Semin. Immunopathol 20 : 133 ~ 147
[학술지(정기간행물)] - Monach, P. A / 2004 / The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease / Adv. Immunol 82 : 217 ~ 248
[학술지(정기간행물)] - Kouskoff, V / 1996 / Organ-specific disease provoked by systemic autoimmunity / Cell 87 : 811 ~ 822
[학술지(정기간행물)] - Korganow, A. S / 1999 / From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins / Immunity 10 : 451 ~ 461
[학술지(정기간행물)] - Brennan, F. M / 1998 / Role of pro-inflammatory cytokines in rheumatoid arthritis / Springer Semin. Immunopathol 20 : 133 ~ 147
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UCI(KEPA) : I410-ECN-0101-2017-517-001849000