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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.3
- 발행연도
- 2017.9
- 수록면
- 166 - 171 (6page)
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In this study, we investigated whether Sargassum yezoense extract (SYE) could inhibit α-glucosidase and α- amylase activities, and alleviate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. Freeze-dried S. yezoense was extracted with 80% ethanol and concentrated for use in this study. The hypoglycemic effect was determined by evaluating the inhibitory activities of SYE against α-glucosidase and α-amylase as well as its ability to decrease postprandial blood glucose levels. The half-maximal inhibitory concentrations of SYE against α-glucosidase and α-amylase were 0.078±0.004 and 0.212±0.064 mg/mL, respectively. SYE was a more effective inhibitor of α-glucosidase and α- amylase activities than the positive control, acarbose. The increase in postprandial blood glucose levels was significantly alleviated in the SYE group compared with that in the control group of STZ-induced diabetic mice. Furthermore, the area under the curves significantly decreased with SYE administration in STZ-induced diabetic mice. These results suggest that SYE is a potent inhibitor of α-glucosidase and α-amylase activities and alleviates postprandial hyperglycemia caused by dietary carbohydrates.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Zimmet P. / 2001 / Global and societal implications of the diabetes epidemic / Nature 414 : 782 ~ 787
[학술지(정기간행물)] - Muoio DM / 2006 / Obesity-related derangements in metabolic regulation / Annu Rev Biochem 75 : 367 ~ 401
[학술지(정기간행물)] - Baron AD. / 1998 / Postprandial hyperglycaemia and a-glucosidase inhibitors / Diabetes Res Clin Pract 40 (suppl) : S51 ~ S55
[학술지(정기간행물)] - Ceriello A / 2005 / Postprandial hyperglycemia and diabetes complications : is it time to treat? / Diabetes 54 : 1 ~ 7
[학술지(정기간행물)] - UK Prospective Diabetes Study(UKPDS)Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes(UKPDS 33) / Lancet 352 : 837 ~ 853
[학술지(정기간행물)] - Muoio DM / 2006 / Obesity-related derangements in metabolic regulation / Annu Rev Biochem 75 : 367 ~ 401
[학술지(정기간행물)] - Baron AD. / 1998 / Postprandial hyperglycaemia and a-glucosidase inhibitors / Diabetes Res Clin Pract 40 (suppl) : S51 ~ S55
[학술지(정기간행물)] - Ceriello A / 2005 / Postprandial hyperglycemia and diabetes complications : is it time to treat? / Diabetes 54 : 1 ~ 7
[학술지(정기간행물)] - UK Prospective Diabetes Study(UKPDS)Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes(UKPDS 33) / Lancet 352 : 837 ~ 853
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UCI(KEPA) : I410-ECN-0101-2018-594-001354774