지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 69 - 77 (9page)
이용수
초록· 키워드
오류제보하기
Background: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging.
Methods: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements.
Results: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture.
Conclusion: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin.
Methods: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements.
Results: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture.
Conclusion: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (43)
참고문헌 신청
[학술지(정기간행물)] - Gilchrest BA / 1992 / Ageing and photoaging of the skin : observations at the cellular and molecular level / Br J Dermatol 127 : 25 ~ 30
[학술지(정기간행물)] - Fisher GJ / 1997 / Pathophysiology of premature skin aging induced by ultraviolet light / N Engl J Med 337 : 1419 ~ 1428
[학술지(정기간행물)] - Rittié L / 2015 / Natural and sun-induced aging of human skin / Cold Spring Harb Perspect Med 5 : a015370 ~
[학술지(정기간행물)] - Polj sak B / 2012 / Intrinsic skin aging : the role of oxidative stress / Acta Dermatovenerol Alp Panonica Adriat 21 : 33 ~ 36
[학술지(정기간행물)] - Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138 : 1462 ~ 1470
[학술지(정기간행물)] - Fisher GJ / 1997 / Pathophysiology of premature skin aging induced by ultraviolet light / N Engl J Med 337 : 1419 ~ 1428
[학술지(정기간행물)] - Rittié L / 2015 / Natural and sun-induced aging of human skin / Cold Spring Harb Perspect Med 5 : a015370 ~
[학술지(정기간행물)] - Polj sak B / 2012 / Intrinsic skin aging : the role of oxidative stress / Acta Dermatovenerol Alp Panonica Adriat 21 : 33 ~ 36
[학술지(정기간행물)] - Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138 : 1462 ~ 1470
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UCI(KEPA) : I410-ECN-0101-2018-524-001598709