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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 534 - 539 (6page)
이용수
초록· 키워드
오류제보하기
Background: Ginsenosides are the main ingredients of ginseng, which, in traditional Eastern medicine, has been claimed to have therapeutic values for many diseases. In order to verify the effects of ginseng that have been empirically observed, we utilized the reverse docking method to screen for target proteins that are linked to specific diseases.
Methods: We constructed a target protein database including 1,078 proteins associated with various kinds of diseases, based on the Potential Drug Target Database, with an added list of kinase proteins. We screened 26 kinds of ginsenosides of this target protein database using docking.
Results: We found four potential target proteins for ginsenosides, based on docking scores. Implications of these “hit” targets are discussed. From this screening, we also found four targets linked to possible side effects and toxicities, based on docking scores.
Conclusion: Our method and results can be helpful for finding new targets and developing new drugs from natural products.
Methods: We constructed a target protein database including 1,078 proteins associated with various kinds of diseases, based on the Potential Drug Target Database, with an added list of kinase proteins. We screened 26 kinds of ginsenosides of this target protein database using docking.
Results: We found four potential target proteins for ginsenosides, based on docking scores. Implications of these “hit” targets are discussed. From this screening, we also found four targets linked to possible side effects and toxicities, based on docking scores.
Conclusion: Our method and results can be helpful for finding new targets and developing new drugs from natural products.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Nocerino E / 2000 / The aphrodisiac and adaptogenic properties of ginseng / Fitoterapia 71 : S1 ~ S5
[학술지(정기간행물)] - Paul N / 2004 / Recovering the true targets of specific ligands by virtual screening of the protein data bank / Proteins Struct Funct Bioinform 54 : 671 ~ 680
[학술지(정기간행물)] - Kharkar PS / 2014 / Reverse docking : a powerful tool for drug repositioning and drug rescue / Fut Med Chem 6 : 333 ~ 342
[학술지(정기간행물)] - Kitchen DB / 2004 / Docking and scoring in virtual screening for drug discovery : methods and applications / Nat Rev Drug Discov 3 : 935 ~ 949
[학술지(정기간행물)] - Chong CR / 2007 / New uses for old drugs / Nature 448 : 645 ~ 646
[학술지(정기간행물)] - Paul N / 2004 / Recovering the true targets of specific ligands by virtual screening of the protein data bank / Proteins Struct Funct Bioinform 54 : 671 ~ 680
[학술지(정기간행물)] - Kharkar PS / 2014 / Reverse docking : a powerful tool for drug repositioning and drug rescue / Fut Med Chem 6 : 333 ~ 342
[학술지(정기간행물)] - Kitchen DB / 2004 / Docking and scoring in virtual screening for drug discovery : methods and applications / Nat Rev Drug Discov 3 : 935 ~ 949
[학술지(정기간행물)] - Chong CR / 2007 / New uses for old drugs / Nature 448 : 645 ~ 646
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UCI(KEPA) : I410-ECN-0101-2018-524-001599302