Anti-Inflammatory and Anti-Obesity Properties of Food Bioactive Components : Effects on Adipose Tissue :Effects on Adipose Tissue

Shasika Jayarathne; Iurii Koboziev; Oak-Hee Park; Wilna Oldewage-Theron; Chwan-Li Shen; Naima Moustaid-Moussa

doi:10.3746/pnf.2017.22.4.251

추천

검색

질문

자료유형: 학술저널

저자정보: Shasika Jayarathne (Texas Tech University) Iurii Koboziev (Texas Tech University) Oak-Hee Park (Texas Tech University) Wilna Oldewage-Theron (Texas Tech University) Chwan-Li Shen (Texas Tech University) Naima Moustaid-Moussa (Texas Tech University)

저널정보: 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.4

발행연도: 2017.12

수록면: 251 - 262 (12page)

DOI: 10.3746/pnf.2017.22.4.251

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Obesity is an epidemic and costly disease affecting 13% of the adult population worldwide. Obesity is associated with adipose tissue hypertrophy and hyperplasia, as well as pathologic endocrine alterations of adipose tissue including local and chronic systemic low-grade inflammation. Moreover, this inflammation is a risk factor for both metabolic syndrome (MetS) and insulin resistance. Basic and clinical studies demonstrate that foods containing bioactive compounds are capable of preventing both obesity and adipose tissue inflammation, improving obesity-associated MetS in human subjects and animal models of obesity. In this review, we discuss the anti-obesity and anti-inflammatory protective effects of some bioactive polyphenols of plant origin and omega-3 polyunsaturated fatty acids, available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. We review how these bioactive compounds modulate cell signaling including through the nuclear factor-κB, adenosine monophosphate-activated protein kinase, mitogen-activated protein kinase, toll-like receptors, and G-protein coupled receptor 120 intracellular signaling pathways and improve the balance of pro- and anti-inflammatory mediators secreted by adipose tissue and subsequently lower systemic inflammation and risk for metabolic diseases.

#obesity #inflammation #polyphenols #omega-3 fatty acids

참고문헌 (127)

참고문헌 신청

Kalupahana NS, Claycombe K, Newman SJ, Stewart T, Siriwardhana N, Matthan N, Lichtenstein AH, Moustaid- Moussa N. 2010. Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. J Nutr 140: 1915-1922. LeMieux MJ, Kalupahana NS, Scoggin S, Moustaid-Moussa N. 2015. Eicosapentaenoic acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity- independent manner. J Nutr 145: 411-417. Torres-Leal FL, Fonseca-Alaniz MH, Rogero MM, Tirapegui J. 2010. The role of inflamed adipose tissue in the insulin resistance. Cell Biochem Funct 28: 623-631. Hotamisligil GS, Erbay E. 2008. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8: 923- 934. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. 2016. Trends in obesity among adults in the United States, 2005 to 2014. JAMA 315: 2284-2291.

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!