개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 661 - 665 (5page)
이용수
초록· 키워드
오류제보하기
We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin (9d-12d) showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Klayman DL / 1985 / Qinghaosu(artemisinin) : an antimalarial drug from China / Science 228 : 1049 ~ 1055
[학술지(정기간행물)] - Lee S / 2007 / Artemisinin, promising lead natural product for various drug developments / Mini Rev Med Chem 7 : 411 ~ 422
[학술지(정기간행물)] - Luo XD / 1987 / The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives / Med Res Rev 7 : 29 ~ 52
[학술지(정기간행물)] - Jung M / 1994 / Current developments in the chemistry of artemisinin and related compounds / Curr Med Chem 1 : 35 ~ 49
[학술지(정기간행물)] - Haynes RK / 1997 / From Qinghao, marvelous herb of antiquity, to the antimalarial trioxane qinghaosu-and some remarkable new chemistry / Acc Chem Res 30 : 73 ~ 79
[학술지(정기간행물)] - Lee S / 2007 / Artemisinin, promising lead natural product for various drug developments / Mini Rev Med Chem 7 : 411 ~ 422
[학술지(정기간행물)] - Luo XD / 1987 / The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives / Med Res Rev 7 : 29 ~ 52
[학술지(정기간행물)] - Jung M / 1994 / Current developments in the chemistry of artemisinin and related compounds / Curr Med Chem 1 : 35 ~ 49
[학술지(정기간행물)] - Haynes RK / 1997 / From Qinghao, marvelous herb of antiquity, to the antimalarial trioxane qinghaosu-and some remarkable new chemistry / Acc Chem Res 30 : 73 ~ 79
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Antithrombotic Effect of Artemisinin through Phosphoprotein Regulation in U46619-induced Platelets
대한의생명과학회지
2023 .09
-
Can Artemisinin Be a Game Changer Even as an Antiarrhythmic Drug?
Korean Circulation Journal
2023 .04
-
Antiarrhythmic Effect of Artemisinin in an Ex-vivo Model of Brugada Syndrome Induced by NS5806
Korean Circulation Journal
2023 .04
-
Molecular Surveillance of Pfkelch13 and Pfmdr1 Mutations in Plasmodium falciparum Isolates from Southern Thailand
Parasites, Hosts and Diseases
2019 .08
-
A pharmacokinetic comparison of homodimer ARB-92 and heterodimer ARB-89: novel, potent antimalarial candidates derived from 7β-hydroxyartemisinin
Journal of Pharmaceutical Investigation
2018 .09
-
Evaluating the activity of N-89 as an oral antimalarial drug
Parasites, Hosts and Diseases
2023 .08
-
Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China
Parasites, Hosts and Diseases
2015 .02
-
A LAMP-SNP Assay Detecting C580Y Mutation in Pfkelch13 Gene from Clinically Dried Blood Spot Samples
Parasites, Hosts and Diseases
2021 .02
-
In Vitro Evaluation of Two Novel Antimalarial Derivatives of SKM13: SKM13-MeO and SKM13-F
Parasites, Hosts and Diseases
2022 .12
-
Monitoring antimalarial drug-resistance markers in Somalia
Parasites, Hosts and Diseases
2023 .02
-
A Case of Segmental Vitiligo with Generalized Morphea Stabilized by Antimalarial Medication
Annals of Dermatology
2016 .01
-
Antimalarial effect of synthetic endoperoxide on synchronized Plasmodium chabaudi infected mice
Parasites, Hosts and Diseases
2023 .02
-
Antimalarial Efficacy of Aqueous Extract of Strychnos ligustrina and Its Combination with Dihydroartemisinin and Piperaquine Phosphate (DHP) against Plasmodium berghei Infection
Parasites, Hosts and Diseases
2022 .10
-
Biologically active compounds from natural and marine natural organisms with antituberculosis, antimalarial, leishmaniasis, trypanosomiasis, anthelmintic, antibacterial, antifungal, antiprotozoal, and antiviral activities
셀메드
2016 .11
-
Artemisinin-loaded niosome and pegylated niosome: physicochemical characterization and effects on MCF-7 cell proliferation
Journal of Pharmaceutical Investigation
2018 .05
-
Determinant of parasite clearance and density on uncomplicated falciparum malaria infections in malaria-endemic area of Lampung Province, Indonesia
Parasites, Hosts and Diseases
2023 .05
-
Anti-malarial effect of PJ extract by inhibiting platelet activation in rodent model
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis
Maxillofacial Plastic Reconstructive Surgery
2021 .01
-
A 13-week repeated dose oral toxicity study on a water extract of Artemisia annua in Sprague-Dawley rat
Journal of Biomedical and Translational Research
2020 .01
-
Concern about the Safety of Bisphenol A Substitutes
Diabetes and Metabolism Journal
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-513-001680472