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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 23 - 29 (7page)
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초록· 키워드
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Ethanol-induced fat accumulation, the earliest and most common response of the liver to ethanol exposure, may be involved in the pathogenesis of liver diseases. Isoliquiritigenin (ISL), an important constituent of Glycyrrhizae Radix, is a chalcone derivative that exhibits antioxidant, anti-inflammatory, and phytoestrogenic activities. However, the effect of ISL treatment on lipid accumulation in hepatocytes and alcoholic hepatitis remains unclear. Therefore, we evaluated the effect and underlying mechanism of ISL on ethanol-induced hepatic steatosis by treating AML-12 cells with 200 mM ethanol and/or ISL (0~50 μM) for 72 hr. Lipid accumulation was assayed by oil red O staining, and the expression of sirtuin1 (SIRT1), sterol regulatory element-binding protein-1c (SREBP-1c), AMP-activated protein kinase (AMPK), and peroxisome proliferator-activated receptor alpha (PPARα) was studied by western blotting. Our results indicated that ISL treatment upregulated SIRT1 expression and downregulated SREBP-1c expression in ethanol-treated cells. Similarly, oil red O staining revealed a decrease in ethanolinduced fat accumulation upon co-treatment of ethanol-treated cells with 10, 20, and 50 μM of ISL. These findings suggest that ISL can reduce ethanol induced-hepatic lipogenesis by activating the SIRT1-AMPK pathway and thus improve lipid metabolism in alcoholic fatty livers.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
O'Shea, R.S. / 2010 / Alcoholic liver disease / Am. J. Gastroenterol. 105:14~32
Watanabe, Y. / 2016 / Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice / Sci. Rep. 6:23097
Gao, B. / 2011 / Alcoholic liver disease: pathogenesis and new therapeutic targets / Gastroenterology 141:1572~1585
Nagy, L.E. / 2016 / Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes / Gastroenterology 150:1756~1768
Lieber, C.S. / 2008 / Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats / Biochem. Biophys. Res. Commun. 370:44~48
Watanabe, Y. / 2016 / Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice / Sci. Rep. 6:23097
Gao, B. / 2011 / Alcoholic liver disease: pathogenesis and new therapeutic targets / Gastroenterology 141:1572~1585
Nagy, L.E. / 2016 / Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes / Gastroenterology 150:1756~1768
Lieber, C.S. / 2008 / Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats / Biochem. Biophys. Res. Commun. 370:44~48
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UCI(KEPA) : I410-ECN-0101-2018-513-001743703