지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 43 - 50 (8page)
- DOI
- 10.15188/kjopp.2018.02.32.1.43
이용수
초록· 키워드
오류제보하기
Korean Red Ginseng (RG) are used as a traditional treatment for improve blood circulation. This experimental study was designed to investigate the inhibitory effects of Korean red ginseng on lipid metabolism in high fat/cholesterol diet (HFCD)-induced hypertriglyceridemia. Sprague Dawley rats were fed the HFCD diet with/without fluvastatin (Flu, positive control) 3 mg/kg/day, and RG 125 or 250 mg/kg/day, respectively. All groups received regular diet or HFCD diet, respectively, for 13 weeks. The last three groups treatment of Flu and RG 125, and RG 250 orally for a period of 9 weeks. Group 1, reular diet; group 2, HFCD diet; group 3, Flu + HFCD diet; group 4, RG 125 + HFCD diet; group 5, RG 250 + HFCD diet. As a result, treatment with low or high doses of RG markedly attenuated plasma levels of triglycerides and augmented plasma levels of high-density lipoprotein (HDL) in HFCD-fed rats. RG and Flu also led to an increase in lipoprotein lipase activity in the HFCD group. On the other hand, RG and Flu led to an decrease in fatty acid synthase and free fatty acid activity in the HFCD group. Treatment with RG suppressed increased expressions of PPAR-α and AMPK in HFCD rat liver or muscle. In addition, the RG attenuated triglyceridemia by inhibition of PPAR-γ and FABP protein expression levels and LXR and SREBP-1 gene expression in liver or muscle. The RG significantly prevented the development of the metabolic disturbances such as hypertriglyceridemia and hyperlipidemia. Taken together, the administration of RG improves hypertriglyceridemia through the alteration in suppression of triglyceride synthesis and accentuated of triglyceride decomposition. These results suggested that RG is useful in the prevention or treatment of hypertriglyceridemia.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (34)
참고문헌 신청
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Janes PJ / 1993 / Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in human / Am J Clin Nutr 57:868~874
신현영 / 2016 / 2014년 사망원인 통계 / 대한의사협회지 59(3):221~232
Michael S. Brown / 1994 / Harrison's Principles Of Internal Medicine / McGraw-Hill :2058
Watts GF / 1992 / Effects on coronary artery disease of lipid lowering diet of diet plus cholestyramine. in the St. Thomas, atherosclerosis regression study (STARS) / Lancet 339:563~569
Janes PJ / 1993 / Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in human / Am J Clin Nutr 57:868~874
신현영 / 2016 / 2014년 사망원인 통계 / 대한의사협회지 59(3):221~232
Michael S. Brown / 1994 / Harrison's Principles Of Internal Medicine / McGraw-Hill :2058
Watts GF / 1992 / Effects on coronary artery disease of lipid lowering diet of diet plus cholestyramine. in the St. Thomas, atherosclerosis regression study (STARS) / Lancet 339:563~569
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UCI(KEPA) : I410-ECN-0101-2018-519-001809151