지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 110 - 117 (8page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural product for application in the development of a treatment for NAFLD.
MATERIALS/METHODS: The preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model. Animals were divided into three groups (n = 7): normal diet group (ND), WD group, and WD plus 1% EAF group.
RESULTS: EAF reduced OA-stimulated lipid accumulation in HepG2 cells in the absence of cellular cytotoxicity and significantly blocked transcriptional activation of sterol regulatory element-binding protein 1 and fatty acid synthase genes. Subsequently, we investigated these effects in vivo in mice fed either ND or WD in the presence or absence of EAF supplementation. In comparison to the ND controls, the WD-fed mice exhibited increases in body weight, liver weight, epididymal fat weight, and accumulation of fat in hepatocytes, and these effects were significantly attenuated by EAF supplementation.
CONCLUSIONS: Allium fistulosum attenuates the development of NAFLD, and EAF elicits anti-lipogenic activity in liver. Therefore, EAF represents a promising candidate for use in the development of novel therapeutic drugs or drug combinations for the prevention and treatment of NAFLD.
MATERIALS/METHODS: The preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model. Animals were divided into three groups (n = 7): normal diet group (ND), WD group, and WD plus 1% EAF group.
RESULTS: EAF reduced OA-stimulated lipid accumulation in HepG2 cells in the absence of cellular cytotoxicity and significantly blocked transcriptional activation of sterol regulatory element-binding protein 1 and fatty acid synthase genes. Subsequently, we investigated these effects in vivo in mice fed either ND or WD in the presence or absence of EAF supplementation. In comparison to the ND controls, the WD-fed mice exhibited increases in body weight, liver weight, epididymal fat weight, and accumulation of fat in hepatocytes, and these effects were significantly attenuated by EAF supplementation.
CONCLUSIONS: Allium fistulosum attenuates the development of NAFLD, and EAF elicits anti-lipogenic activity in liver. Therefore, EAF represents a promising candidate for use in the development of novel therapeutic drugs or drug combinations for the prevention and treatment of NAFLD.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease
Nutrition Research and Practice
2018 .04
-
Impact of dietary fiber intake on nonalcoholic fatty liver disease risk in Korean patients with obesity and type 2 diabetes mellitus
Journal of Nutrition and Health
2024 .06
-
Association Between Protein Intake From Different Animal and Plant Origins and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study
Clinical Nutrition Research
2023 .01
-
Association between Inflammatory Biomarkers and Nutritional Status in Fatty Liver
Clinical Nutrition Research
2020 .01
-
Association of energy intake with handgrip strength in Korean adults with non-alcoholic fatty liver disease
Journal of Nutrition and Health
2022 .12
-
Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages
Nutrition Research and Practice
2015 .12
-
Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages
Nutrition Research and Practice
2015 .12
-
Increased Hepatic Lipogenesis Elevates Liver Cholesterol Content
Molecules and Cells
2021 .01
-
Optimization of technical methods for applying new technique to biomolecule separation: Electrical Asymmetrical Flow Field-Flow Fractionation (EAF4)
한국분석과학회 학술대회
2018 .11
-
Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells
Nutrition Research and Practice
2019 .06
-
Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells
Nutrition Research and Practice
2019 .06
-
The Effect of Nutrition Education Program on Overweight/Obese Patients with Non-Alcoholic Fatty Liver Disease: a Single-Blind Parallel Randomized Controlled Trial
Clinical Nutrition Research
2019 .01
-
Differential Effects of Western and High-fat Diets on the Acceleration of Psoriatic Inflammation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .12
-
유리지방산으로 지방축적을 유도한 HepG2 cells 대한 꾸지뽕 열매 추출물의 개선 효과
생명과학회지
2019 .10
-
Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study
Clinical Nutrition Research
2020 .01
-
A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
Clinical Nutrition Research
2020 .01
-
Development and Application of Low-Carbohydrates and Low-Simple Sugar Nutrition Education Materials for Non-Alcoholic Fatty Liver Disease Patients
Clinical Nutrition Research
2015 .01
-
Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats
Nutrition Research and Practice
2020 .12
-
Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats
Nutrition Research and Practice
2020 .12
-
The Chromatin Accessibility Landscape of Nonalcoholic Fatty Liver Disease Progression
Molecules and Cells
2022 .05
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-594-001904758