지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 116 - 124 (9page)
이용수
초록· 키워드
오류제보하기
Lysozyme is known as a key substance of the innate immunity and have antibacterial effect in the mucosal tissues, especially middle ear. Aquaporin (AQP) functions as water movement in the tissue and has been expected to be participated in the inflammatory responses. In the present study, we investigated to reveal association of lysozymes and AQPs in otitis media. The gene expression of lysozyme genes, homo sapiens lysozyme (hLYZ), homo sapiens lysozyme M (hLYZ M), and homo sapiens lysozyme G like-2 (hLYGH), and AQP genes (AQP 0 - AQP 12) were measured from postauricular skin, mastoid mucosa, inflamed mastoid mucosa, and middle ear mucosa. The hLYZ, hLYZ M and hLYGH gene were expressed in mastoid mucosa, inflamed mastoid mucosa, middle ear mucosa. Of AQP genes, all AQP gene except AQP 3 gene were expressed in the tissue of middle ear. Among them, AQP 4, AQP 8, AQP 9, AQP 10, AQP 11 and AQP 12 were highly expressed in the inflamed mastoid mucosa and normal mastoid mucosa (P<0.001). Interestingly, expression levels of AQP 4, AQP 9, and AQP 12 gene were significantly higher in the inflamed mastoid mucosa compared to normal middle ear mucosa (P<0.05). These results suggest that lysozyme and AQPs could be associated with inflammatory response in the middle ear.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Agre P / 1993 / Aquaporin CHIP: the archetypal molecular water channel / American Journal of Physiology 265:463~476
Denker BM / 1988 / Identification purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules / The Journal of Biological Chemistry 263:15634~15642
Dibas AI / 1998 / Aquaporins (water channels): role in vasopressin-activated water transport / Proceedings of the Society for Experimental Biology and Medicine 219:183~199
Elkjaer ML / 2001 / Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways / American Journal of Physiology-Renal Physiology 281:1047~1057
Ganz T / 2004 / Antimicrobial polypeptides / journal of leukocyte biology 75:34~38
Denker BM / 1988 / Identification purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules / The Journal of Biological Chemistry 263:15634~15642
Dibas AI / 1998 / Aquaporins (water channels): role in vasopressin-activated water transport / Proceedings of the Society for Experimental Biology and Medicine 219:183~199
Elkjaer ML / 2001 / Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways / American Journal of Physiology-Renal Physiology 281:1047~1057
Ganz T / 2004 / Antimicrobial polypeptides / journal of leukocyte biology 75:34~38
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