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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.2
- 발행연도
- 2018.6
- 수록면
- 102 - 107 (6page)
- DOI
- 10.3746/pnf.2018.23.2.102
이용수
초록· 키워드
오류제보하기
The Phaseolus vulgaris (common bean), a worldwide vegetable of high consumption, can act as a nutritional supplement in the diet of oversized individuals to reduce weight. Studies have demonstrated the existence of molecules capable of inhibiting the breakdown of carbohydrates via inhibition of both α-amylases and glycosidases. Here, we describe a novel property of the Phaseolus vulgaris: inhibition of thrombotic cardiovascular events. Using assays to test platelet aggregation and secretion, and flow cytometry against the surface expression of P-Selectin. We show that bean extracts significantly reduced adenosine 5’-diphosphate and arachidonic acid induced-platelet aggregation. The mechanism underlying such effect appears to be mediated by AKT, since AKT hypo-phosphorylation decreases the “inside out” activation of platelets. In sum, our results support the hypothesis that common beans are nutritional ingredients that help reduce the risk of cardiovascular diseases associated with platelet hyper-reactivity.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
[단행본] - WHO / 2011 / Global atlas on cardiovascular disease prevention and control: policies, strategies and interventions : 4 ~ 8
[학술지(정기간행물)] - Smith SC Jr / 2012 / Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke) / J Am Coll Cardiol 60 : 2343 ~ 2348
[학술지(정기간행물)] - Mimura J / 2015 / Role of Nrf2 in the pathogenesis of atherosclerosis / Free Radic Biol Med 88 : 221 ~ 232
[학술지(정기간행물)] - Willeit J / 2000 / Biology of arterial atheroma / Cerebrovasc Dis 10 : 1 ~ 8
[학술지(정기간행물)] - Grove EL / 2015 / Antiplatelet therapy in acute coronary syndromes / Expert Opin Pharmacother 16 : 2133 ~ 2147
[학술지(정기간행물)] - Smith SC Jr / 2012 / Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke) / J Am Coll Cardiol 60 : 2343 ~ 2348
[학술지(정기간행물)] - Mimura J / 2015 / Role of Nrf2 in the pathogenesis of atherosclerosis / Free Radic Biol Med 88 : 221 ~ 232
[학술지(정기간행물)] - Willeit J / 2000 / Biology of arterial atheroma / Cerebrovasc Dis 10 : 1 ~ 8
[학술지(정기간행물)] - Grove EL / 2015 / Antiplatelet therapy in acute coronary syndromes / Expert Opin Pharmacother 16 : 2133 ~ 2147
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UCI(KEPA) : I410-ECN-0101-2018-594-003146187