지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 327 - 333 (7page)
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초록· 키워드
오류제보하기
Background: Bioactive compounds in plant extracts are able to reduce metal ions to nanoparticles through the process of green synthesis. Panax ginseng is an oriental medicinal herb and an adaptogen which has been historically used to cure various diseases. In addition, the P. ginseng leaves-mediated gold nanoparticles are the value-added novel materials. Its potential as a cosmetic ingredient is still unexplored. The aim of this study was to evaluate the antioxidant, moisture retention and whitening properties of gold nanoparticles (PgAuNPs) in cosmetic applications.
Methods: Cell-free experiments were performed to evaluate PgAuNP’s antioxidant and moisture retention properties and inhibition activity on mushroom tyrosinase. Furthermore, in vitro cell cytotoxicity was evaluated using normal human dermal fibroblast and murine B16BL6 melanoma cells (B16) after treatment with increasing concentrations of PgAuNPs for 24 h, 48 h, and 72 h. Finally, in vitro cell assays on B16 cells were performed to evaluate the whitening effect of PgAuNPs through reduction of cellular melanin content and tyrosinase activity.
Results: In vitro DPPH radical scavenging assay results revealed that PgAuNPs exhibited antioxidant activity in a dose-dependent manner. PgAuNPs exhibited moisture retention capacity and effectively inhibited mushroom tyrosinase. In addition, 3-(4,5-dimethyl-thiazol-2yl)-2,5-diphenyl tetrazolium bromide results revealed that PgAuNPs were not toxic to human dermal fibroblast and B16 cells; in addition, they significantly reduced melanin content, tyrosinase activity, and mRNA expression of melanogenesis-associated transcription factor and tyrosinase in B16 cells.
Conclusion: Our study is the first report to provide evidence supporting that P. ginseng leaves-capped gold nanoparticles could be used as multifunctional ingredients in cosmetics.
Methods: Cell-free experiments were performed to evaluate PgAuNP’s antioxidant and moisture retention properties and inhibition activity on mushroom tyrosinase. Furthermore, in vitro cell cytotoxicity was evaluated using normal human dermal fibroblast and murine B16BL6 melanoma cells (B16) after treatment with increasing concentrations of PgAuNPs for 24 h, 48 h, and 72 h. Finally, in vitro cell assays on B16 cells were performed to evaluate the whitening effect of PgAuNPs through reduction of cellular melanin content and tyrosinase activity.
Results: In vitro DPPH radical scavenging assay results revealed that PgAuNPs exhibited antioxidant activity in a dose-dependent manner. PgAuNPs exhibited moisture retention capacity and effectively inhibited mushroom tyrosinase. In addition, 3-(4,5-dimethyl-thiazol-2yl)-2,5-diphenyl tetrazolium bromide results revealed that PgAuNPs were not toxic to human dermal fibroblast and B16 cells; in addition, they significantly reduced melanin content, tyrosinase activity, and mRNA expression of melanogenesis-associated transcription factor and tyrosinase in B16 cells.
Conclusion: Our study is the first report to provide evidence supporting that P. ginseng leaves-capped gold nanoparticles could be used as multifunctional ingredients in cosmetics.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
References
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Wickens AP / 2001 / Ageing and the free radical theory / Respir Physiol 128 : 379 ~ 391
[학술지(정기간행물)] - Luft R / 1994 / The development of mitochondrial medicine / Proc Natl Acad Sci 91 : 8731 ~ 8738
[학술지(정기간행물)] - Kim YJ / 2005 / Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future / Cell Mol Life Sci 62 : 1707 ~ 1723
[학술지(정기간행물)] - Solano F / 2006 / Hypopigmenting agents: an updated review on biological, chemical and clinical aspects / Pigment Cell Res 19 : 550 ~ 571
[단행본] - Frenk E / 1995 / Treatment of melasma with depigmenting agents;Melasma: new approaches to treatment / Martin Dunitz Ltd : 9 ~ 15
[학술지(정기간행물)] - Luft R / 1994 / The development of mitochondrial medicine / Proc Natl Acad Sci 91 : 8731 ~ 8738
[학술지(정기간행물)] - Kim YJ / 2005 / Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future / Cell Mol Life Sci 62 : 1707 ~ 1723
[학술지(정기간행물)] - Solano F / 2006 / Hypopigmenting agents: an updated review on biological, chemical and clinical aspects / Pigment Cell Res 19 : 550 ~ 571
[단행본] - Frenk E / 1995 / Treatment of melasma with depigmenting agents;Melasma: new approaches to treatment / Martin Dunitz Ltd : 9 ~ 15
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UCI(KEPA) : I410-ECN-0101-2018-524-003161206