Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats

Wahiba Amraoui; Nesrine Adjabi; Fatiha Bououza; Mahieddine Boumendjel; Faiza Taibi; Amel Boumendjel; Cherif Abdennour; Mahfoud Messarah

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저자정보: Wahiba Amraoui (Badji Mokhtar University) Nesrine Adjabi (Badji Mokhtar University) Fatiha Bououza (Badji Mokhtar University) Mahieddine Boumendjel (Badji Mokhtar University) Faiza Taibi (Badji Mokhtar University) Amel Boumendjel (Badji Mokhtar University) Cherif Abdennour (Badji Mokhtar University) Mahfoud Messarah (Badji Mokhtar University)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.34 No.3

발행연도: 2018.7

수록면: 231 - 239 (9page)

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Bisphenol A, an everywhere chemical, is applied as a plasticizer in polycarbonate plastics, which often used in our everyday products and in epoxy resins as protective coatings and linings for food and beverage cans for decades. Human exposure to BPA may lead to adverse effects by interfering with oestrogen receptors. Our present study was conducted to investigate the protective effects of selenium (Se) and vitamin E (Vit E) on BPA-induced damage in the liver of male rats. Animals were randomly divided into four groups: the first group received olive oil and served as control. The second group received both (Se + Vit E) (0.5 ㎎/㎏ diet; 100 ㎎/㎏ of diet). The third one treated orally by (10 ㎎/㎏ b.w.) of BPA. The last group received (Se + Vit E) (0.5 ㎎/㎏ diet; 100 ㎎/㎏ of diet) concomitantly with (10 ㎎/㎏ b.w.) BPA. Exposure to BPA for three weeks engendered a hepatic disorder. An increased AST and ALT enzymatic activity was noticed in BPA-treated group as compared to other groups. Furthermore, a change in glucose, cholesterol, LDL-C, HDL-C, albumin, and bilirubin level was remarkable. Moreover, exposure to BPA increased malondialdehyde levels while reduced gluthatione content was decreased in the liver homogenate. A decrease in glutathione peroxidase, glutathione s-transferase and catalase activities was observed in the same group. Administration of selenium and vitamin E through the diet in BPA treated rats ameliorated the biochemical parameters cited above. In addition, an improvement in activities of liver enzymes was recorded. The histological findings confirmed the biochemical results. The model of this study that we employed characterized the relationships between BPA-induced hepatotoxicity and its alleviation by natural antioxidants like selenium and vitamin E.

#Bisphenol A #Selenium #Vitamin E #Hepatotoxicity #Oxidative stress #Rat

참고문헌 (58)

참고문헌 신청

INRS / 2016 / Fiche Toxicologique No 279 Edition 03/11/2013 Et Le 01/01/2016

Takeshita, A. / 2001 / Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription / Eur. J. Endocrinol. 145:513~517

Kang, J.H. / 2006 / Human exposure to bisphenol A / Toxicology 226:79~89

Anjum, S. / 2011 / Melatonin ameliorates bisphenol a-induced biochemical toxicity in testicular mitochondria of mouse / Food Chem. Toxicol. 49:2849~2854

고아라 / 2014 / Association between Urinary Bisphenol A and Waist Circumference in Korean Adults / 한국독성학회지 30(1):39~44

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