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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 429 - 435 (7page)
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초록· 키워드
오류제보하기
Toxoplasma gondii is a ubiquitous protozoan parasite responsible for causing toxoplasmosis. Preventive measures for toxoplasmosis are currently lacking and as such, development of novel vaccines are of urgent need. In this study, we generated 2 virus-like particles (VLPs) vaccines expressing T. gondii rhoptry protein 4 (ROP4) or rhoptry protein 18 (ROP18) using influenza matrix protein (M1) as a core protein. Mice were intranasally immunized with VLPs vaccines and after the last immunization, mice were challenged with ME49 cysts. Protective efficacy was assessed and compared by determining serum antibody responses, body weight changes and the reduction of cyst counts in the brain. ROP18 VLPs-immunized mice induced greater levels of IgG and IgA antibody responses than those immunized with ROP4 VLPs. ROP18 VLPs immunization significantly reduced body weight loss and the number of brain cysts in mice compared to ROP4 VLPs post-challenge. These results indicate that T. gondii ROP18 VLPs elicited better protective efficacy than ROP4 VLPs, providing important insight into vaccine design strategy.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Parlog A / 2015 / Toxoplasma gondii-induced neuronal alterations / Parasite Immunol 37 : 159 ~ 170
[학술지(정기간행물)] - Tenter AM / 2000 / Toxoplasma gondii: from animals to humans / Int J Parasitol 30 : 1217 ~ 1258
[학술지(정기간행물)] - Jones JL / 2014 / Neglected parasitic infections in the United States: toxoplasmosis / Am J Trop Med Hyg 90 : 794 ~ 799
[학술지(정기간행물)] - Goldstein EJC / 2008 / Management of Toxoplasma gondii infection during pregnancy / Clin Infect Dis 47 : 554 ~ 566
[학술지(정기간행물)] - Liu Q / 2012 / Vaccines against Toxoplasma gondii:status, challenges and future directions / Hum Vaccin Immunother 8 : 1305 ~ 1308
[학술지(정기간행물)] - Tenter AM / 2000 / Toxoplasma gondii: from animals to humans / Int J Parasitol 30 : 1217 ~ 1258
[학술지(정기간행물)] - Jones JL / 2014 / Neglected parasitic infections in the United States: toxoplasmosis / Am J Trop Med Hyg 90 : 794 ~ 799
[학술지(정기간행물)] - Goldstein EJC / 2008 / Management of Toxoplasma gondii infection during pregnancy / Clin Infect Dis 47 : 554 ~ 566
[학술지(정기간행물)] - Liu Q / 2012 / Vaccines against Toxoplasma gondii:status, challenges and future directions / Hum Vaccin Immunother 8 : 1305 ~ 1308
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