지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 524 - 531 (8page)
이용수
초록· 키워드
오류제보하기
Background: Fermented black ginseng (FBG) is produced through several cycles of steam treatment of raw ginseng, at which point its color turns black. During this process, the original ginsenoside components of raw ginseng (e.g., Re, Rg1, Rb1, Rc, and Rb2) are altered, and less-polar ginsenosides are generated (e.g., Rg3, Rg5, Rk1, and Rh4). The aim of this study was to determine the effect of FBG on wound healing.
Methods: The effects of FBG on tube formation and on scratch wound healing were measured using human umbilical vein endothelial cells (HUVECs) and HaCaT cells, respectively. Protein phosphorylation of mitogen-activated protein kinase was evaluated via Western blotting. Finally, the wound-healing effects of FBG were assessed using an experimental cutaneous wounds model in mice.
Results and Conclusion: The results showed that FBG enhanced the tube formation in HUVECs and migration in HaCaT cells. Western blot analysis revealed that FBG stimulated the phosphorylation of p38 and extracellular signal-regulated kinase in HaCaT cells. Moreover, mice treated with 25 ㎍/mL of FBG exhibited faster wound closure than the control mice did in the experimental cutaneous wounds model in mice.
Methods: The effects of FBG on tube formation and on scratch wound healing were measured using human umbilical vein endothelial cells (HUVECs) and HaCaT cells, respectively. Protein phosphorylation of mitogen-activated protein kinase was evaluated via Western blotting. Finally, the wound-healing effects of FBG were assessed using an experimental cutaneous wounds model in mice.
Results and Conclusion: The results showed that FBG enhanced the tube formation in HUVECs and migration in HaCaT cells. Western blot analysis revealed that FBG stimulated the phosphorylation of p38 and extracellular signal-regulated kinase in HaCaT cells. Moreover, mice treated with 25 ㎍/mL of FBG exhibited faster wound closure than the control mice did in the experimental cutaneous wounds model in mice.
목차
abstract
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - 김대원 / 2015 / PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury / BMB Reports 48 (11) : 618 ~ 623
[학술지(정기간행물)] - Sung-Hee Hwang / 2016 / Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling / Journal of Ginseng Research 40 (4) : 325 ~ 333
[학술지(정기간행물)] - Watelet JB / 2002 / Wound healing of the respiratory mucosa: a review / Am J Rhinol 16 : 77 ~ 84
[학술지(정기간행물)] - Hosemann W / 1991 / Normal wound healing of the paranasal sinuses: clinical and experimental investigations / Eur Arch Otorhinolaryngol 248 : 390 ~ 394
[학술지(정기간행물)] - Li J / 2003 / Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix / Microsc Res Tech 60 : 107 ~ 114
[학술지(정기간행물)] - Sung-Hee Hwang / 2016 / Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling / Journal of Ginseng Research 40 (4) : 325 ~ 333
[학술지(정기간행물)] - Watelet JB / 2002 / Wound healing of the respiratory mucosa: a review / Am J Rhinol 16 : 77 ~ 84
[학술지(정기간행물)] - Hosemann W / 1991 / Normal wound healing of the paranasal sinuses: clinical and experimental investigations / Eur Arch Otorhinolaryngol 248 : 390 ~ 394
[학술지(정기간행물)] - Li J / 2003 / Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix / Microsc Res Tech 60 : 107 ~ 114
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