지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 93 - 101 (9page)
이용수
초록· 키워드
오류제보하기
Tetrabromobisphenol A (TBBPA), the most common industrial brominated flame retardant, acts as a cytotoxic, neurotoxic, and immunotoxicant, causing inflammation and tumors. However, the mechanism of TBBPA-induced matrix metalloproteinase-9 (MMP-9) expression in human breast cancer cells is not clear. In human breast cancer MCF-7 cells, treatment with TBBPA significantly induced the expression and promoter activity of MMP-9. Transient transfection with MMP-9 mutation promoter constructs verified that NF-κB and AP-1 response elements are responsible for the effects of TBBPA. Furthermore, TBBPA-induced MMP-9 expression was mediated by NF-κB and AP-1 transcription activation as a result of the phosphorylation of the Akt and MAPK signaling pathways. Moreover, TBBPA-induced activation of Akt/MAPK pathways and MMP-9 expression were attenuated by a specific NADPH oxidase inhibitor, and the ROS scavenger. These results suggest that TBBPA can induce cancer cell metastasis by releasing MMP-9 via ROS-dependent MAPK, and Akt pathways in MCF-7 cells.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
de Wit, C.A. / 2002 / An overview of brominated flame retardants in the environment / Chemosphere 46:583~624
Berger, U. / 2004 / Two trace analytical methods for determination of hydroxylated PCBs and other halogenated phenolic compounds in eggs from Norwegian birds of prey / Anal. Chem 76:441~452
Birnbaum, L.S. / 2004 / Brominated flame retardants: cause for concern? / Environ. Health Perspect 112:9~17
Morris, S. / 2004 / Distribution and fate of HBCD and TBBPA brominated flame retardants in North Sea estuaries and aquatic food webs / Environ. Sci. Technol 38:5497~5504
Saint-Louis, R. / 2004 / LC-ESI-MS-MS method for the analysis of tetrabromobisphenol A in sediment and sewage sludge / Analyst 129:724~730
Berger, U. / 2004 / Two trace analytical methods for determination of hydroxylated PCBs and other halogenated phenolic compounds in eggs from Norwegian birds of prey / Anal. Chem 76:441~452
Birnbaum, L.S. / 2004 / Brominated flame retardants: cause for concern? / Environ. Health Perspect 112:9~17
Morris, S. / 2004 / Distribution and fate of HBCD and TBBPA brominated flame retardants in North Sea estuaries and aquatic food webs / Environ. Sci. Technol 38:5497~5504
Saint-Louis, R. / 2004 / LC-ESI-MS-MS method for the analysis of tetrabromobisphenol A in sediment and sewage sludge / Analyst 129:724~730
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UCI(KEPA) : I410-ECN-0101-2019-513-000294512