지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Cerebral ischemia results from a variety of causes that cerebral blood flow is reduced due to a transient or permanent occlusion of cerebral arteries. Reactive astrocytes and microglial activation plays an important role in the neuronal cell death during ischemic insult. Acupunctural treatment is effective for symptom improvement in cerebrovascular accident, including cerebral ischemia.
Methods: In the present study, the effects of acupuncture at the ST40 acupoint on short-term memory and apoptosis in the hippocampal CA1 region following transient global cerebral ischemia were investigated using gerbils. Transient global ischemia was induced by occlusion of both common carotid arteries with aneurysm clips for 5 min. Acupuncture stimulation was conducted once daily for 7 consecutive days, starting one day after surgery.
Results: In the present results, ischemia induction deteriorated short term memory, increased apoptosis, and induced reactive astrocyte and microglial activation. Acupuncture at ST40 acupoint ameliorated ischemia-induced short-term memory impairment by suppressing apoptosis in the hippocampus through down-regulation of reactive astrocytes and microglial activation.
Conclusion: The present study suggests that acupuncture at the ST40 acupoint can be used for treatment of patients with cerebral stroke.
Methods: In the present study, the effects of acupuncture at the ST40 acupoint on short-term memory and apoptosis in the hippocampal CA1 region following transient global cerebral ischemia were investigated using gerbils. Transient global ischemia was induced by occlusion of both common carotid arteries with aneurysm clips for 5 min. Acupuncture stimulation was conducted once daily for 7 consecutive days, starting one day after surgery.
Results: In the present results, ischemia induction deteriorated short term memory, increased apoptosis, and induced reactive astrocyte and microglial activation. Acupuncture at ST40 acupoint ameliorated ischemia-induced short-term memory impairment by suppressing apoptosis in the hippocampus through down-regulation of reactive astrocytes and microglial activation.
Conclusion: The present study suggests that acupuncture at the ST40 acupoint can be used for treatment of patients with cerebral stroke.
목차
Introduction
Materials and method
Results
Discussion
Conclusion
References
참고문헌 (54)
참고문헌 신청
Leker RR / 2002 / Cerebral ischemia and trauma-different etiologies yet similar mechanisms : Neuroprotective opportunities / Brain Res Brain Res Rev 39(1):55~73
Block F / 1999 / Global ischemia and behavioural deficits / Prog Neurobiol 58(3):279~295
Olsson T / 2003 / Brain damage in a mouse model of global cerebral ischemia. Effect of nmda receptor blockade / Brain Res 982(2):260~269
Ma B / 2008 / Protective effects of extract of Coeloglossum viride var. Bracteatum on ischemia-induced neuronal death and cognitive impairment in rats / Behav Pharmacol 19(4):325~333
Min D / 2012 / Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils / Neurosci Lett 510(1):29~33
Block F / 1999 / Global ischemia and behavioural deficits / Prog Neurobiol 58(3):279~295
Olsson T / 2003 / Brain damage in a mouse model of global cerebral ischemia. Effect of nmda receptor blockade / Brain Res 982(2):260~269
Ma B / 2008 / Protective effects of extract of Coeloglossum viride var. Bracteatum on ischemia-induced neuronal death and cognitive impairment in rats / Behav Pharmacol 19(4):325~333
Min D / 2012 / Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils / Neurosci Lett 510(1):29~33
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UCI(KEPA) : I410-ECN-0101-2019-519-000328775