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논문 기본 정보

자료유형
학술저널
저자정보
Min-Seok Cho (Catholic University of Pusan) Hae-Woong Park (Catholic University of Pusan) Gil-Hyun Lee (Dong-Eui University) Hae-Gyung Yoon (Dong-eui University) Kyung-Mo Oh (Busan Kyungsang College) Seok-Cheol Choi (Catholic University of Pusan) Kyung-Yae Hyun (Dong-Eui University)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제25권 제1호
발행연도
2019.3
수록면
83 - 91 (9page)

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초록· 키워드

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This study was undertaken to investigate the therapeutic effect of Angelica acutiloba on allergic dermatitis, which Angelica acutiloba is traditionally known to have antiinflammatory effects. Sprague-Dawley (SD) rats were divided into five groups: normal control group, experimental allergic dermatitis group (vehicle group), low dose of Angelica acutiloba extract (low-dose group), high dose of Angelica acutiloba extract (high-dose group), and antihistamine treated group with experimental dermatitis (antihistamine group). Total leukocyte, neutrophil, lymphocyte, monocyte and eosinophil counts were significantly higher in the vehicle group than in the control group, but these variables were significantly lower in the low- and high-dose groups than in the vehicle group. The platelet/lymphocyte ratio in the red blood cell index was significantly lower in the low- and high-dose groups than in the vehicle group. Low and high doses of the Angelica acutiloba extract did not have toxic effects on liver and kidney. Serum NO, iNOS and levels were highest in the vehicle group but significantly lower in the low- and high-dose groups, especially in the high-dose group. The results of this study suggested that the Angelica acutiloba extract had the effect of alleviating or treating the experimental allergic dermatitis, and it was concluded that the high dose was more effective.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2019-510-000546407