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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 456 - 463 (8page)
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초록· 키워드
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The present study examined the effects of Korean white ginseng (WG, Panax ginseng C. A. Meyer) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered with saline or WG (WG 100 or 300 ㎎/㎏, p.o.) daily for 21 days. The cognitive improving efficacy of WG on the amnesic rats, which was induced by TMT, was investigated by assessing the Morris water maze test and by performing immunohistochemistries on choline acetyltransferase (ChAT), acetylcholinesterase (AchE), cAMP responsive element binding protein (CREB) and brain derived neurotrophic factor (BDNF). The rats treated with TMT injection (control group) showed impaired learning and memory of the tasks, but the rats treated with TMT injection and WG administration produced significant improvement of the escape latency to find the platform in the Morris water maze at the 2nd and 4th days compared to that of the control group. In the retention test, the WG 100 and WG 300 groups showed significantly increased crossing number around the platform compared to that of the control group (p<0.001). Consistently with the behavioral data, result of immunohistochemistry analysis showed that WG 100 ㎎/㎏ significantly alleviated the loss of BDNF-ir neurons in the hippocampus compared to that of the control group (p<0.01). Also, treatment with WG has a trend to be increased the cholinergic neurons in the hippocampal CA1 and CA3 areas as compared to that of the control group. These results suggest that WG may be useful for improving the cognitive function via regulation of neurotrophic activity.
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참고문헌 (29)
참고문헌 신청
Balaban CD / 1988 / Trimethyltin-induced neuronal damage in the rat brain: comparative studies using silver degeneration strains, immunocytochemistry and immune-assay for neuronotypic and gliotypic proteins / Neuroscience 26:337~361
Balin B / 2011 / Toward a unifying hypothesis in the devleopment of Alzheimer's disease / CNS Neuroscience &Therapeutics 17:587~589
Castren E / 1995 / Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus / Neuroscience 64:71~80
Chang LW / 1983 / A time-course study of trimethyltin induced neuropathology in rats / Neurobehavioral Toxicology and Teratology 5:43~49
Chang LW / 1985 / Septotemporal gradients of trimethyltin-induced hippocampal lesions / Neurobehavioral Toxicology and Teratology 7:43~49
Balin B / 2011 / Toward a unifying hypothesis in the devleopment of Alzheimer's disease / CNS Neuroscience &Therapeutics 17:587~589
Castren E / 1995 / Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus / Neuroscience 64:71~80
Chang LW / 1983 / A time-course study of trimethyltin induced neuropathology in rats / Neurobehavioral Toxicology and Teratology 5:43~49
Chang LW / 1985 / Septotemporal gradients of trimethyltin-induced hippocampal lesions / Neurobehavioral Toxicology and Teratology 7:43~49
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UCI(KEPA) : I410-ECN-0101-2019-480-000589985