지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 42 - 54 (13page)
- DOI
- 10.7783/KJMCS.2018.26.1.42
이용수
초록· 키워드
오류제보하기
Background: Allergic diseases like such as atopic dermatitis, asthma, and rhinitis have recently increased both domestically and globally. The present study was undertaken to select candidates with anti-allergic activity from plant resources.
Methods and Results: Fifty-six plant extracts at 20㎍/㎖ were screened against β-hexosaminidase production and interleukin (IL)- 4 release in degranulated rat basophilic leukemia (RBL)-2H3 cells. The anti-allergy activity of three plant extracts selected from the preliminary screening experiment, Polygonatum sibiricum F. Delaroche (root), Pyrus pytifolia var. culta (Makino) Nakai (leaf), and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud (root) were measured at concentrations of 2 - 250㎍/㎖ in three cell lines as RBL- 2H3, HaCaT and Jurkcat T cells. The assay showed the root extract of R. glutinosa to have an inhibitory activity of 4.2% - 28.6% on β-hexosaminidase production from IgE-sensitized RBL-2H3 cells. Each extract of P. sibiricum and R. glutinosa reduced IL-4 release in IgE-sensitized RBL-2H3 cells, respectively. The leaf extract of P. pyrifolia var. culta showed a significantly potent suppressive effect of 10.2% - 74.7% on the mRNA expression of tumor necrosis factor (TNF)-α in HaCaT cells sensitized with TNF-a and INF-g, and showed inhibitory effect of –8.6% - 90.9% on the mRNA expression of IL-2 in Jurkat T cells sensitized with PMA and A23187.
Conclusions: The results showed that the root of R. glutinosa and leaf of P. pyrifolia var. culta could be useful candidates as antiallergy materials.
Methods and Results: Fifty-six plant extracts at 20㎍/㎖ were screened against β-hexosaminidase production and interleukin (IL)- 4 release in degranulated rat basophilic leukemia (RBL)-2H3 cells. The anti-allergy activity of three plant extracts selected from the preliminary screening experiment, Polygonatum sibiricum F. Delaroche (root), Pyrus pytifolia var. culta (Makino) Nakai (leaf), and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud (root) were measured at concentrations of 2 - 250㎍/㎖ in three cell lines as RBL- 2H3, HaCaT and Jurkcat T cells. The assay showed the root extract of R. glutinosa to have an inhibitory activity of 4.2% - 28.6% on β-hexosaminidase production from IgE-sensitized RBL-2H3 cells. Each extract of P. sibiricum and R. glutinosa reduced IL-4 release in IgE-sensitized RBL-2H3 cells, respectively. The leaf extract of P. pyrifolia var. culta showed a significantly potent suppressive effect of 10.2% - 74.7% on the mRNA expression of tumor necrosis factor (TNF)-α in HaCaT cells sensitized with TNF-a and INF-g, and showed inhibitory effect of –8.6% - 90.9% on the mRNA expression of IL-2 in Jurkat T cells sensitized with PMA and A23187.
Conclusions: The results showed that the root of R. glutinosa and leaf of P. pyrifolia var. culta could be useful candidates as antiallergy materials.
목차
ABSTRACT
서언
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (25)
참고문헌 신청
반학진 / 2012 / 艾葉의 RBL-2H3 비만세포 탈과립, cytokine 생산 및 FcεRI 유전자 발현에 미치는 영향 / 동의생리병리학회지 26(6):915~921
Brown JM / 2007 / The mast cell and allergic disease: Role in pathogenesis and implications for therapy / Clinical and Experimental Allergy 38:4~18
Cheng C / 2013 / Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models / Allergy 68:195~203
Choi JK / 2017 / Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes / Food and Chemical Toxicology 110:142~150
정용준 / 2013 / 갈근과 옻 혼합추출물의 성분변화 및 항알러지 효과 / 한국자원식물학회지 26(1):103~110
Brown JM / 2007 / The mast cell and allergic disease: Role in pathogenesis and implications for therapy / Clinical and Experimental Allergy 38:4~18
Cheng C / 2013 / Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models / Allergy 68:195~203
Choi JK / 2017 / Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes / Food and Chemical Toxicology 110:142~150
정용준 / 2013 / 갈근과 옻 혼합추출물의 성분변화 및 항알러지 효과 / 한국자원식물학회지 26(1):103~110
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