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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.8
- 수록면
- 191 - 197 (7page)
- DOI
- 10.15188/kjopp.2019.08.33.4.191
이용수
초록· 키워드
오류제보하기
This study aims to evaluate the effects of the root bark of Morus alba (RMA) on the regulation of the Hippo-YAP pathway. Hippo-YAP signaling is a critical regulator in controlling organ size and tissue homeostasis. Hippo, the serine/threonine kinase phosphorylate the LATS. Phosphorylated LATS then phosphorylates and inactivates the YAP and TAZ, which are two closely related transcriptional co-activator. Here we report RMA activates the Hippo signaling, thereby inhibits the YAP/TAZ activity. First, we examine the cytotoxic effects of RMA by MTT assay. RMA was cytotoxic at concentrations higher than 50 μg/ml in HEK293A cells. The reporter gene assay was performed to measure the activity of TEAD, a key transcription factor that controls cell growth and proliferation. RMA significantly suppressed the luciferase activity. By phos-taq gel shift assay, and western blotting, we showed that RMA enhanced the phosphorylation of YAP in wild type cells, but not in LATS1/2 knock out cells, which means RMA activates classical Hippo pathway. RMA induced the cytoplasmic sequestration of YAP. RMA also suppressed the mRNA expression of CTGF and CYR61; the two major YAP dependent genes. Taken together, RMA is considered to be a good candidate for proliferative disease such as cancer, by facilitating cell death through activating the Hippo signaling pathway.
목차
서론
재료 및 방법
결과
고찰
References
참고문헌 (38)
참고문헌 신청
Pan D / 2010 / The hippo signaling pathway in development and cancer / Developmental cell 19(4):491~505
Harvey KF / 2013 / The Hippo pathway and human cancer / Nat Rev Cancer 13(4):246~257
Zhao B / 2010 / The Hippo-YAP pathway in organ size control and tumorigenesis : an updated version / Genes & development 24(9):862~874
Mo JS / 2014 / The Hippo signaling pathway in stem cell biology and cancer / EMBO reports 15(6):642~656
Moroishi T / 2015 / The emerging roles of YAP and TAZ in cancer / Nat Rev Cancer 15(2):73~79
Harvey KF / 2013 / The Hippo pathway and human cancer / Nat Rev Cancer 13(4):246~257
Zhao B / 2010 / The Hippo-YAP pathway in organ size control and tumorigenesis : an updated version / Genes & development 24(9):862~874
Mo JS / 2014 / The Hippo signaling pathway in stem cell biology and cancer / EMBO reports 15(6):642~656
Moroishi T / 2015 / The emerging roles of YAP and TAZ in cancer / Nat Rev Cancer 15(2):73~79
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