지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The most frequently encountered problems at fixture-implantation sites are lack of adequate bone and proximity to anatomic structures. It is generally accepted that growth factors play an essential role in the healing process and tissue formation, and they have become the focus of grafting materials research. The granules in platelets contain high concentrations of various growth factors. In particular, platelet-rich fibrin (PRF) is a second-generation platelet concentrate that allows the production of fibrin membranes enriched with platelets and growth factors from an anticoagulant-free blood harvest. This study investigated the in vitro effects of PRF on osteoblasts, in terms of the key cellular functions, and especially the effects on two growth factors, the homodimer of platelet-derived growth factor subunit B (BPDGF-BB) and transforming growth factor (TGF)-b1, which are associated with wound healing and regeneration (i.e., proliferation and differentiation). The following parameters were investigated: PDGF-BB and TGF-b1 levels in PRF, cell viability, alkaline phosphatase (ALP) activity, type 1 collagen synthesis, and the expressions of osteoblast differentiation markers (ALP and runt-related transcription factor 2) and bone matrix proteins (type 1 collagen). The release of autologous growth factors from PRF was maintained for a reasonable period of time, and exerted positive effects on the proliferation and differentiation of osteoblasts. The use of PRF thus appears to be a promising method for enhancing bone healing and remodeling.
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참고문헌 (23)
참고문헌 신청
Celotti F / 2006 / Effect of platelet-rich plasma on migration and proliferation of SaOS-2 osteoblasts: role of plateletderived growth factor and transforming growth factor-
Cenni E / 2005 / Effects of activated platelet concentrates on human primary cultures of fibroblasts and osteoblasts / J Periodontol 76 : 323 ~ 328
Choukroun J / 2001 / Une opportunite en paro-implantologie / Implantodontie 42 : 55 ~ 62
Cypher TJ / 1996 / Biological principles of bone graft healing / J Foot Ankle Surg 35 : 413 ~ 417
Dohan DM / 2006 / PRP, cPRP, PRF, PRG, PRGF, FC How to find your way in the jungle of platelet concentrates? / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 : 305 ~ 3
Cenni E / 2005 / Effects of activated platelet concentrates on human primary cultures of fibroblasts and osteoblasts / J Periodontol 76 : 323 ~ 328
Choukroun J / 2001 / Une opportunite en paro-implantologie / Implantodontie 42 : 55 ~ 62
Cypher TJ / 1996 / Biological principles of bone graft healing / J Foot Ankle Surg 35 : 413 ~ 417
Dohan DM / 2006 / PRP, cPRP, PRF, PRG, PRGF, FC How to find your way in the jungle of platelet concentrates? / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 : 305 ~ 3
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