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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 44 - 50 (7page)
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초록· 키워드
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Purpose : Better understanding of the epidemiology of Streptococcus pneumoniae affects
preventive and therapeutic strategies for children with otitis media. This study was undertaken
to examine the prevalence of pneumococcal serotypes causing otitis media in
children.
Methods : Pneumococcal isolates obtained from the ear discharge of children with otitis
media between January 2001 and December 2006 were characterized by serotyping and
antibiotic susceptibility testing.
Results : There were 54 pneumococcal isolates from 54 children with otitis media. The
median age of patients was 13 months, and the proportion of children ＜5 years old was
81%. The predominant serotypes, in order of decreasing frequency, were 19A (44%), 19F
(28%), 6B (7%), 6A (4%), 9V (4%), and 1 (4%); 23 isolates (43%) belonged to types included
in the heptavalent pneumococcal conjugate vaccine (PCV7). The proportion of serotype
19A and 19F accounted for 72% of overall pneumococcal isolates, which accounted
for 84% of pneumococcal isolates from otorrhea of children <5 years old (vs 20% in children
≥5 years old, P<0.001). All serotypes isolated from 3 vaccinees of PCV7 were 19A.
There was no significant diminution in otitis media caused by pneumococcal vaccine serotypes
after the introduction of PCV7. The frequency of nonsusceptibility to penicillin, erythromycin,
and trimethoprim-sulfamethoxazole was higher in serotype 19A than in other
non-vaccine serotypes, respectively. The frequency of multiple drug resistance was 96% in
serotype 19A, compared with 29% in other non-vaccine serotypes (P=0.001).
Conclus ion : 19A was the most common pneumococcal serotype causing otitis media and
represented a large proportion of strains with multiple drug resistance in children younger
than 5 years of age. (Korean J Pediatr Infect Dis 2008;15:44-50)
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참고문헌 (24)
참고문헌 신청
Belshe RB / 2004 / Current status of live attenuated influenza virus vaccine in the US / Virus Res 103 : 177 ~ 185
Black S / 2000 / Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Gro
Block SL / 1997 / Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media / Pediatr Infect Dis J 16 : 449 ~ 456
Dagan R / 1996 / Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine / J Infect Dis 174 : 1271
Dagan R / 2000 / Acute otitis media caused by antibioticresistant Streptococcus pneumoniae in southern Israel: implication for immunizing with conjugate vaccines / J Infect
Black S / 2000 / Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Gro
Block SL / 1997 / Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media / Pediatr Infect Dis J 16 : 449 ~ 456
Dagan R / 1996 / Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine / J Infect Dis 174 : 1271
Dagan R / 2000 / Acute otitis media caused by antibioticresistant Streptococcus pneumoniae in southern Israel: implication for immunizing with conjugate vaccines / J Infect
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