High Expression of Ribonucleotide Reductase Subunit M2 Correlates with Poor Prognosis of Hepatocellular Carcinoma

이보인; 하상윤; 송대현; 이현우; 조수연; 박철근

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자료유형: 학술저널

저자정보: 이보인 하상윤 송대현 이현우 조수연 박철근

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제8권 제6호

발행연도: 2014.1

수록면: 662 - 668 (7page)

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Background/Aims: Ribonucleotide reductase subunit M2 (RRM2) catalyzes the production of deoxynucleotide triphos-phates, which are necessary for DNA synthesis. RRM2 has been reported to play an active role in tumor progression, and elevated RRM2 levels have been correlated with poor prognosis for colorectal cancer patients. This study aimed to elucidate the prognostic significance of RRM2 protein ex-pression in hepatocellular carcinoma after surgery. Methods: RRM2 protein expression was evaluated using immunohisto-chemistry in tumor tissues from 259 hepatocellular carcino-ma patients who underwent curative hepatectomy. Results: High RRM2 expression was observed in 210 of 259 patients (81.1%) with hepatocellular carcinomas. High RRM2 expres-sion was significantly associated with viral etiology (p=0.035) and liver cirrhosis (p=0.036). High RRM2 expression was correlated with early recurrence (p=0.004) but not with late recurrence (p=0.144). Logistic regression analysis revealed that high RRM2 expression (p=0.040) and intrahepatic metastasis (p<0.001) were independent predictors of early recurrence. High RRM2 expression unfavorably influenced both shorter recurrence-free survival (p=0.011) and shorter disease-specific survival (p=0.002) and was an independent predictor of shorter disease-specific survival (p=0.008). Conclusions: High RRM2 protein expression might be a useful marker for predicting early recurrence and may be a marker for poor prognosis of hepatocellular carcinoma after curative hepatectomy.

#Ribonucleotide reductase subunit M2 #Hepato-cellular carcinoma #Survival

참고문헌 (26)

참고문헌 신청

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안수민 / 2013 / Metadherin Is a Prognostic Predictor of Hepatocellular Carcinoma after Curative Hepatectomy / Gut and Liver 7(2):206~212

Zhou BS / 1998 / Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential / Clin Exp Metastasis 16:43~49

Duxbury MS / 2007 / RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness / Biochem Biophys Res Commun 354:190~196

D’Angiolella V / 2012 / Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair / Cell 149 : 1023 ~ 1034