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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 381 - 387 (7page)
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Background/Aims: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the pathogenic mechanism of microscopic colitis. Methods: This study consisted of six patients with lymphocytic colitis, six patients with collagenous colitis, and six patients with functional diarrhea but normal pathology. We performed an immunohistochemical analysis of the colonic mucosal biopsies to assess the expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-κB, interferon-γ, inducible nitric oxide synthase, and tumor necrosis factor-α. We compared the quantity score of immunohistochemical staining among the groups. Results: The microscopic colitis group showed significantly higher expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-κB, and interferon-γ compared with the control group. Cytokine expression was similar between collagenous colitis and lymphocytic colitis. However, the expression of cyclo-oxygenase-2 was higher in collagenous colitis. Conclusions: Proinflammatory cytokines, including interleukin-17 and interferon-γ, are highly expressed in microscopic colitis. The expression of cyclo-oxygenase-2 was higher in collagenous colitis than in lymphocytic colitis. This study is the first on interleukin-17 expression in microscopic colitis patients.
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참고문헌 (26)
참고문헌 신청
Andresen L / 2005 / Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis / Gut 54 : 503 ~ 509
Casellas i Jorda F / 2004 / TNF-alpha inhibitors in inflammatory bowel disease / Med Clin 123 : 627 ~ 634
Dey I / 2013 / Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4 / PLoS One 8 : e61891 ~
Esteve M / 2011 / Effi
Fitzpatrick LR / 2012 / Novel pharmacological approaches for inflammatory bowel disease: targeting key intracellular pathways and the IL-23/IL-17 axis / Int J Inflam 2012 :
Casellas i Jorda F / 2004 / TNF-alpha inhibitors in inflammatory bowel disease / Med Clin 123 : 627 ~ 634
Dey I / 2013 / Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4 / PLoS One 8 : e61891 ~
Esteve M / 2011 / Effi
Fitzpatrick LR / 2012 / Novel pharmacological approaches for inflammatory bowel disease: targeting key intracellular pathways and the IL-23/IL-17 axis / Int J Inflam 2012 :
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