지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 295 - 306 (12page)
이용수
초록· 키워드
오류제보하기
Crohn’s disease (CD) and ulcerative colitis (UC) have features that suggest bacterial involvement, and all genetic models of inflammatory bowel disease (IBD)require the presence of commensal bacteria. CD is associated with innate immune response genes such as NOD2/CARD15 and the autophagy genes ATG16L1 and IRGM. However, IBD responds to immunosuppression,suggesting that any bacteria involved are not acting as conventional pathogens.
Molecular techniques are rapidly advancing our knowledge of the gut microbiota. In CD there is reduced diversity,and notably a reduction in the probiotic Faecalibacterium prausnitzii, the presence of which in the terminal ileum is associated with a reduced risk of recurrence following surgery. There is also a consistent increase in mucosa-associated Escherichia coli with an “adherent and invasive” phenotype, which allows them to replicate inside macrophages and induce granulomas. Speculation that CD could be caused by the Mycobacterium avium subspecies paratuberculosis (MAP) continues. The response to antitumor necrosis factor treatments suggests that, if relevant at all, MAP is not acting as a conventional pathogen. However,there is increased colonization by MAP in CD, and there is evidence that it could have an indirect effect mediated by the suppression of macrophage function.
UC relapse is frequently associated with infection by pathogens, but there is less evidence for involvement of a specific bacterial species. Poor barrier integrity followed by an inflammatory reaction to bacterial components,with chronicity maintained by an autoimmune process, seems a plausible pathogenic model.
Bacterial theories of pathogenesis are now becoming testable by targeted therapeutic interventions.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Barnich N / 2004 / Involvement of lipoprotein NlpI in the virulence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease / Infect I
Boudeau J / 1999 / Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease / Infect Immun 67 : 4499 ~ 4509
Bringer MA / 2006 / The Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 replicates in mature phagolysosomes within J774 macrophages / Cell Microbio
Darfeuille-Michaud A / 1998 / Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease / Gastroenterology 115 : 1405 ~ 1413
Glasser AL / 2001 / Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death /
Boudeau J / 1999 / Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease / Infect Immun 67 : 4499 ~ 4509
Bringer MA / 2006 / The Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 replicates in mature phagolysosomes within J774 macrophages / Cell Microbio
Darfeuille-Michaud A / 1998 / Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease / Gastroenterology 115 : 1405 ~ 1413
Glasser AL / 2001 / Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death /
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