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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 409 - 416 (8page)
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Background/Aims: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Methods: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). Results: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (≤5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p<0.001), respectively. Elevated serum α-fetoprotein (AFP) (>20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p<0.001), respectively.
Tumor size (>5 cm), multinodularity, elevated serum AFP (>20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS. Conclusions: In patients treated with TACE as a first therapy, tumor size (≤5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (>20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS.
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참고문헌 (23)
참고문헌 신청
Arimura E / 2005 / Local recurrence is an important prognostic factor of hepatocellular carcinoma / World J Gastroenterol 11 : 5601 ~ 5606
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / Hepatology 53 : 1020 ~ 1022
Cabibbo G / 2011 / Predicting survival in patients with hepatocellular carcinoma treated by transarterial chemoembolisation / Aliment Pharmacol Ther 34 : 196 ~ 204
Ebied OM / 2003 / Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma / Cancer 97 : 1042 ~ 1050
El-Serag HB / 2008 / Diagnosis and treatment of hepatocellular carcinoma / Gastroenterology 134 : 1752 ~ 1763
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / Hepatology 53 : 1020 ~ 1022
Cabibbo G / 2011 / Predicting survival in patients with hepatocellular carcinoma treated by transarterial chemoembolisation / Aliment Pharmacol Ther 34 : 196 ~ 204
Ebied OM / 2003 / Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma / Cancer 97 : 1042 ~ 1050
El-Serag HB / 2008 / Diagnosis and treatment of hepatocellular carcinoma / Gastroenterology 134 : 1752 ~ 1763
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