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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 446 - 455 (10page)
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Background/Aims: Several studies have demonstrated that serum interferon-γ-inducible-protein-10 (IP-10) levels at baseline and single nucleotide polymorphisms (SNPs) near the IL28B gene were associated with viral response and treatment outcomes. Our purpose was to assess the combination of pretreatment IP-10 levels with IL28B SNPs as predictors of treatment response to pegylated interferon α-2a plus ribavirin in patients infected with genotype 1 hepatitis C virus in China. Methods: Seventy-two patients with chronic hepatitis C without fibrosis/cirrhosis were enrolled in the study. The virologic parameters and baseline serum IP-10 levels were determined. IL-28B genotypes were determined by sequencing.
Results: In this cohort, serum baseline IP-10 levels lower than 426.7 pg/mL could predict rapid virological response/ sustained virological response (SVR). Patients carrying favorable IL28B SNP genotypes had higher SVRs than did those carrying unfavorable variants (IL28B rs12979860, p=0.002; IL28B rs8099917, p=0.020). Combining both baseline IP- 10 and IL28B SNPs could improve the prediction of SVR in favorable allele carriers of IL28B, rs12979860 CC and rs8099917 TT. Serum baseline IP-10 levels and IL28B genotypes were independent predictors of SVR. Conclusions: Our study shows that the combination of baseline serum IP-10 levels and the determination of IL28B SNPs increase the predictability of SVR rates in this cohort.
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참고문헌 (40)
참고문헌 신청
Mohd Hanafiah K / 2013 / Global epidemiology of hepatitis C virus infection: new estimates of agespecific antibody to HCV seroprevalence / Hepatology 57:1333~1342
Lavanchy D / 2009 / The global burden of hepatitis C / Liver Int 29(1):74~81
Ly KN / 2012 / The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007 / Ann Intern Med 156:271~278
McHutchison JG / 1998 / Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group / N Engl J Med 339:1485~1492
Yu ML / 2009 / Treatment of chronic hepatitis C in Asia:when East meets West / J Gastroenterol Hepatol 24:336~345
Lavanchy D / 2009 / The global burden of hepatitis C / Liver Int 29(1):74~81
Ly KN / 2012 / The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007 / Ann Intern Med 156:271~278
McHutchison JG / 1998 / Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group / N Engl J Med 339:1485~1492
Yu ML / 2009 / Treatment of chronic hepatitis C in Asia:when East meets West / J Gastroenterol Hepatol 24:336~345
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