지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 581 - 586 (6page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are commonly prescribed for stress ulcer prophylaxis (SUP) in critically ill patients. Several studies have suggested that the use of PPIs is a potential risk factor for Clostridium difficile infection (CDI).
We compared the incidences of CDI in the PPI group and H2RA group for SUP in critically ill patients. Methods: From August 2005 to July 2012, the incidences of CDI were retrospectively analyzed in patients who were admitted directly to intensive care units and stayed for more than 3 days.
SUP-related CDI was defined as a CDI diagnosed during the SUP period. Patient clinical data were analyzed to identify potential risk factors for SUP-related CDI. Results: Of the 1,005 patients enrolled (444 patients received PPI and 561 received H2RA), 38 (3.8%) were diagnosed with SUP-related CDI. The incidence of SUP-related CDI was considerably higher in patients who received PPI than in those who received H2RA (6.7% vs 1.8%). PPI use for SUP (odds ratio [OR], 3.3; confidence interval [CI], 1.5 to 7.1; p=0.003) and diabetes mellitus (OR, 2.3; CI, 1.2 to 4.7; p=0.019) were independent risk factors for SUP-related CDI. Conclusions: PPI therapy is associated with a higher risk of SUP-related CDI than H2RA therapy in critically ill patients.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Kenneally C / 2007 / Analysis of 30-day mortality for clostridium difficile-associated disease in the ICU setting / Chest 132:418~424
도영석 / 2014 / Long-Term Clinical Outcome of Clostridium difficile Infection in Hospitalized Patients: A Single Center Study / Intestinal research 12(4):299~305
Sesler JM / 2007 / Stress-related mucosal disease in the intensive care unit:an update on prophylaxis / AACN Adv Crit Care 18:119~126
Quenot JP / 2008 / Bedside adherence to clinical practice guidelines in the intensive care unit: the TECLA study / Intensive Care Med 34:1393~1400
Cook DJ / 1994 / Risk factors for gastrointestinal bleeding in critically ill patients: Canadian Critical Care Trials Group / N Engl J Med 330:377~381
도영석 / 2014 / Long-Term Clinical Outcome of Clostridium difficile Infection in Hospitalized Patients: A Single Center Study / Intestinal research 12(4):299~305
Sesler JM / 2007 / Stress-related mucosal disease in the intensive care unit:an update on prophylaxis / AACN Adv Crit Care 18:119~126
Quenot JP / 2008 / Bedside adherence to clinical practice guidelines in the intensive care unit: the TECLA study / Intensive Care Med 34:1393~1400
Cook DJ / 1994 / Risk factors for gastrointestinal bleeding in critically ill patients: Canadian Critical Care Trials Group / N Engl J Med 330:377~381
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