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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 151 - 160 (10page)
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초록· 키워드
오류제보하기
Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR)genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Baglietto L / 2010 / Risks of Lynch syndrome cancers for MSH6 mutation carriers / J Natl Cancer Inst 102 : 193 ~ 201
Chang DK / 2000 / Steady-s
Chhibber V / 2008 / MSH-6: extending the reliability of immunohistochemistry as a screening tool in Muir-Torre syndrome / Modern Pathology 21 : 159 ~ 164
Choi YH / 2009 / Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario / Hered Cancer Clin Pract 7 : 1
Geary J / 2008 / Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC) / Fam Cancer 7 : 163 ~ 172
Chang DK / 2000 / Steady-s
Chhibber V / 2008 / MSH-6: extending the reliability of immunohistochemistry as a screening tool in Muir-Torre syndrome / Modern Pathology 21 : 159 ~ 164
Choi YH / 2009 / Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario / Hered Cancer Clin Pract 7 : 1
Geary J / 2008 / Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC) / Fam Cancer 7 : 163 ~ 172
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One case of endometrial cancer occurrence: Over 10 years after colon cancer in Lynch family
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Contribution of the MLH1 -93G>A Promoter Polymorphism in Modulating Susceptibility Risk in Malaysian Colorectal Cancer Patients
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