An Improved Auto-Generation System to Obtain  Reference Intervals for Laboratory Medicine

김형회; 홍해숙; 김신영; 트란퉁; 이지민; 김화선; 조훈

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자료유형: 학술저널

저자정보: 김형회 홍해숙 김신영 트란퉁 이지민 김화선 조훈

저널정보: 대한의료정보학회 Healthcare Informatics Research Healthcare Informatics Research 제16권 제1호

발행연도: 2010.1

수록면: 15 - 21 (7page)

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Objectives: Reference values are highly required parameters for all tests in the clinical laboratory, and the supplementary provision of reliable reference intervals is an important task for both clinical laboratories and diagnostic test manufacturers. Despite the progress that has been made in the conceptual aspects of reference intervals, in practice their use is still not completely satisfactory. Most of the laboratories have used various methods to calculate statistic-based reference intervals,and they have mainly focused on extracted data, yet its use is considerably limited. We had to deal with the inconvenience of using a number of programs (SPSS or SAS, MS Excel) in order to calculate the results of reference intervals. Methods: In order to obtain standardized reference intervals, we developed an integrated program that can calculate, by a nonparametric method, reference intervals with using the Clinical and Laboratory Standards Institute (CLSI) processes as its guideline. We also developed a grouping interface that enables users to customize classification of each group (age, gender, blood group,race, etc) when calculating reference intervals. Results: To verify the developed program, we compared the reference intervals of the current data on 281 persons for 8 total areas, and the reference intervals were was already calculated beforehand with by using this new program. As a result, both results perfectly matched. Conclusions: This integrated program will be convenience for calculating reasonable values through continual datainspection at an inspection lab for calculating reference intervals. The newly developed program will improve the consistency and reliability of the statistics on reference intervals.

#Reference Values #Diagnostic Test

참고문헌 (17)

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Berg B / 1981 / Practical experience in the selection and preparation of reference individuals: empirical testing of the provisional Scandinavian recommendations in Reference values in l

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Dybkaer R / 1982 / International federation of clinical chemistry (IFCC)1),2) the theory of reference values. Part 6. Presentation of observed values related to reference va

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