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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Intima-media thickness (IMT) of the carotid artery serves as a marker of general atherosclerosis
and the association of IMT with ischemic stroke has been documented. The purpose of our study is to explore
whether carotid IMT is related with intracranial artery stenosis. Methods: We collected data of B-mode ultrasonographic
measurements of carotid IMT and 3D-TOF MRA from 156 acute ischemic stroke patients admitted to
Hallym University Sacred Heart Hospital between April in 2003 and March in 2004. The mean age was 65.5¡¾
11.4 years (37 to 84 years) and 53.2 percent were male. Based on MRA finding, intracranial artery stenosis was
defined as 50% or more narrowing of major intracranial artery. We divided these subjects into two groups (nostenosis
vs. stenosis) and compared carotid IMT and various vascular risk factors with the stenosis of intracranial
artery. Results: Of 156 patients, 85 had stenosis of intracranial artery on brain MRA. We found significant difference
in age and carotid IMT, but not in other stroke risk factors between two groups. The carotid IMT was 0.72¡¾
0.14 mm for the no-stenosis and 0.83¡¾0.20 mm for the stenosis (p<0.001). When we divided stenosis group into
two subgroups (unifocal vs. multifocal or diffuse), the carotid IMT was 0.76¡¾0.15 mm for unifocal stenosis and
0 . 8 6¡¾0.21 mm for multifocal or diffuse stenosis (p<0.001). The age and carotid IMT were associated with
intracranial stenosis independently on multivariate logistic regression procedure. Conclusions: The present study
provides supportive evidence that carotid IMT is related to stenosis of intracranial artery.
(Korean Journal of Stroke 2005;7(2): 179~185)
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