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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제14권 제3호
- 발행연도
- 2011.1
- 수록면
- 209 - 221 (13page)
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Obesity is significantly increasing in Korean adolescents and nonalcoholic fatty liver disease (NAFLD) is soon expected to be the most common chronic liver disease in children. The symptoms of NAFLD run a broad spectrum and NAFLD in children can lead to the development of nonalcoholic steatohepatitis, cirrhosis and end-stage liver disease, hepatocellular carcinoma (HCC), and can increases the risk of type 2 diabetes and cardiovascular disease. Definitive diagnosis can be achieved with liver biopsy. However, recent advances have shown alternative methods of screening and following patients with noninvasive biomarkers and radiologic imaging studies. The histopathology differs between children and adults, and the mechanism is expected to differ as well. Several factors, such as genes and environmental stressors work intricately to produce NAFLD. Promising medications have been reported for the management of NAFLD. However, their therapeutic effectiveness has yet to be determined. Dietary and exercise interventions remain the mainstay of treatment. By maintaining an interest in obesity and NALFD in children, NAFLD should be diagnosed early and appropriate lifestyle changes should be counseled and encouraged. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 209∼221)
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참고문헌 (27)
참고문헌 신청
Alisi A / 2010 / Nonalcoholic fatty liver disease in children / Curr Opin Clin Nutr Metab Care 13 : 397 ~ 402
Argo CK / 2009 / Systematic review of risk factors for fibrosis progression in nonalcoholic steatohepatitis / J Hepatol 51 : 371 ~ 379
Barshop NJ / 2009 / Nonalcoholic fatty liver disease as a comorbidity of childhood obesity / Pediatr Health 3 : 271 ~ 281
Feldstein AE / 2009 / The natural history of nonalcoholic fatty liver disease in children: a follow-up study for up to 20 years / Gut 58 : 1538 ~ 1544
Fraser A / 2007 / Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004 / Gastroenterology 133 : 1814 ~ 1820
Argo CK / 2009 / Systematic review of risk factors for fibrosis progression in nonalcoholic steatohepatitis / J Hepatol 51 : 371 ~ 379
Barshop NJ / 2009 / Nonalcoholic fatty liver disease as a comorbidity of childhood obesity / Pediatr Health 3 : 271 ~ 281
Feldstein AE / 2009 / The natural history of nonalcoholic fatty liver disease in children: a follow-up study for up to 20 years / Gut 58 : 1538 ~ 1544
Fraser A / 2007 / Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004 / Gastroenterology 133 : 1814 ~ 1820
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