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Background and Purpose The purpose of this meta-analysis was to determine the precise association between beta-2 adrenergic receptor (β2AR) polymorphism and Ischemic stroke.
Methods Published case control studies on association between β2AR and ischemic stroke were searched from electronic databases. Pooled Odds ratio and 95% Confidence interval were calculated by using software RevMan version 5.2.
Results A total of three studies involving 1,642 cases and 1,673 controls, which were published from 2007 to 2014, were subjected to meta-analysis for allelic association and 518 cases and 510 controls for genotypic association. Pooled analysis of two studies for genotypic association suggested that subjects carrying Gln27Glu polymorphism of β2AR had an increased risk for Ischemic stroke under recessive model (OR 2.09; 95% CI; 1.20 to 3.64) and under dominant model (OR 1.47; 95% CI 1.14 to 1.90). Pooled analysis of three studies for allelic association showed a significantly higher Glu27 allele of β2AR in the patients with ischemic stroke (OR 1.58; 95% CI; 1.38 to 1.81).
Conclusions The present meta-analysis suggests that Gln27Glu polymorphism of β2AR gene is associated with increased risk for ischemic stroke.
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참고문헌 (20)
참고문헌 신청
Barbato E / 2007 / GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease / Atherosclerosis 194 : e80 ~
Carlsson M / 2001 / Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabe
Chung KY / 2011 / Conformational changes in the G protein Gs induced by the β2 adrenergic receptor / Nature 477 : 611 ~ 615
Fantidis P / 2010 / The role of intracellular 3’5’-cyclic adenosine monophosphate(cAMP)in atherosclerosis / Curr Vasc Pharmacol 8 : 464 ~ 472
Feigin VL / 2014 / Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 / Lancet 383 : 245 ~ 254
Carlsson M / 2001 / Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabe
Chung KY / 2011 / Conformational changes in the G protein Gs induced by the β2 adrenergic receptor / Nature 477 : 611 ~ 615
Fantidis P / 2010 / The role of intracellular 3’5’-cyclic adenosine monophosphate(cAMP)in atherosclerosis / Curr Vasc Pharmacol 8 : 464 ~ 472
Feigin VL / 2014 / Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 / Lancet 383 : 245 ~ 254
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