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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background and Purpose Large cohort studies on relationship between family history of stroke(FHS) and stroke risk are lacking in Asians. We aimed to systematically evaluate the association ofFHS with stroke risk in a cohort study of 0.5 million Chinese adults.
Methods Information about FHS was self-reported. The median follow-up time was 7.16 years andthe end-point of follow-up was incident stroke, which was entered directly into the China KadoorieBiobank system. Multivariate analyses were performed with Cox proportional hazards model, andinteraction analyses were carried using likelihood-ratio tests.
Results Compared with participants without FHS, the hazard ratio (HR) (95% confidence interval,CI) of stroke for participants with FHS was 1.50 (1.46-1.55). The HRs increased with the number offirst degree relatives with stroke (HRs=1.41, 1.98 and 2.47 for 1, 2 and ≥3 relatives, respectively,Ptrend <0.001). The HRs were 1.57 (95% CI: 1.50-1.66) and 1.49 (95% CI: 1.45-1.54) for siblinghistory and parental history, respectively. Similar associations with offspring stroke risk wereobserved between paternal history (HR=1.48, 95% CI: 1.43-1.54) and maternal history (HR=1.49,95% CI: 1.43-1.55). Moreover, significant interactions were detected between FHS and health-riskbehaviors (tobacco smoking and alcohol drinking).
Conclusions FHS is an independent risk factor for stroke in Chinese. The more first degree relativesare affected by stroke, the higher are individuals’ risk of suffering from stroke. The management ofthe health-risk behaviors for reducing stroke should be highlighted, especially for the individualswith FHS.
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참고문헌 (23)
참고문헌 신청
Caicoya M / 1999 / Family history and stroke:a community case-control study in Asturias, Spain / J Epidemiol Biostat 4 : 313 ~ 320
Chen Z / 2005 / Cohort profile: the Kadoorie Study of Chronic Disease in China (KSCDC) / Int J Epidemiol 34 : 1243 ~ 1249
Chen Z / 2011 / China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up / Int J Epidemiol 40 : 1652 ~ 1666
Choi JC / 2009 / Family history and risk for ischemic stroke: sibling history is more strongly correlated with the disease than parental history / J Neurol Sci 284 : 29 ~ 32
Eguchi E / 2012 / Parental history and lifestyle behaviors in relation to mortality from stroke among Japanese men and women: the Japan Collaborative Cohort Study / J Epidemi
Chen Z / 2005 / Cohort profile: the Kadoorie Study of Chronic Disease in China (KSCDC) / Int J Epidemiol 34 : 1243 ~ 1249
Chen Z / 2011 / China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up / Int J Epidemiol 40 : 1652 ~ 1666
Choi JC / 2009 / Family history and risk for ischemic stroke: sibling history is more strongly correlated with the disease than parental history / J Neurol Sci 284 : 29 ~ 32
Eguchi E / 2012 / Parental history and lifestyle behaviors in relation to mortality from stroke among Japanese men and women: the Japan Collaborative Cohort Study / J Epidemi
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