지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제16권 제2호
- 발행연도
- 2011.1
- 수록면
- 67 - 72 (6page)
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The roles of estrogen and its receptors are important for control of puberty, pubertal growth spurt, epiphyseal fusion of long bone, and accretion of bone mineral content in adolescent. But, the mechanism of functions of them is not fully understood.
The female mice with tissue-specific knock out (KO) of estrogen receptor (ER) were generated to determine the roles of them in the growth and reproductive axis.
The serum levels of growth hormone (GH) were decreased but the body lengths were not in somatotrope-specific ERα KO mice compared with wild ones.
The onset of puberty was delayed in gonadotropin releasing hormone (GnRH) neuron -specific ERα KO mice.
The reproductive axis was disturbed in gonadotrope-specific ERα KO mice.
Additional studies are required to evaluate the various roles of estrogen and its receptors in growth and pubertal development.
Future works will focus on the phenomes of tissue-specific KO of ERβ or aromatase in mice, other animal models, and in vitro or vivo studies of ER agonists or antagonists. (J Korean Soc Pediatr Endocrinol 2011;16:67-72)
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참고문헌 (26)
참고문헌 신청
Borjesson AE / 2010 / The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth / J Bone Miner Res 25 : 2690 ~ 2700
Caligioni CS / 2009 / Assessing reproductive status/stages in mice / Curr Protoc Neurosci 48 (4) : 1 ~ 8
Chagin AS / 2007 / Oestrogen receptors and linear bone growth / Acta Paediatr 96 : 1275 ~ 1279
Chen M / 2009 / Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology / Mol Cell Biochem 321 : 145 ~ 153
Couse JF / 1999 / Estrogen receptor null mice: what have we learned and where will they lead us / Endocr Rev 20 : 358 ~ 417
Caligioni CS / 2009 / Assessing reproductive status/stages in mice / Curr Protoc Neurosci 48 (4) : 1 ~ 8
Chagin AS / 2007 / Oestrogen receptors and linear bone growth / Acta Paediatr 96 : 1275 ~ 1279
Chen M / 2009 / Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology / Mol Cell Biochem 321 : 145 ~ 153
Couse JF / 1999 / Estrogen receptor null mice: what have we learned and where will they lead us / Endocr Rev 20 : 358 ~ 417
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