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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제20권 제2호
- 발행연도
- 2015.1
- 수록면
- 86 - 91 (6page)
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Purpose: To describe the clinical characteristics of full-term neonates with hypocalcemia and to suggest factors associated with neonatal hypocalcemia Methods: The medical records of full-term neonates with hypocalcemia were reviewed.
Hypocalcemia was defined as an ionized calcium (iCa) concentration of <4 mg/dL. Parathyroid hormone (PTH) insufficiency was defined as a serum PTH level of <60 pg/mL or a serum phosphorus level higher than the serum calcium level in the presence of hypocalcemia.
Results: Fifty-three neonates were enrolled. The median age at diagnosis of hypocalcemia was 3 days. In all the neonates, formula feeding predominance was observed. Thirty-eight neonates (69.8%) were compatible with PTH insufficiency.
The number of formula-fed neonates was significantly higher than that of breastfed patients among neonates with PTH insufficiency (P=0.017). Intact PTH was negatively correlated with serum phosphorus levels. Twelve out of 14 neonates (85.7%) had 25-hydroxy vitamin D (25OHD) levels <20 ng/mL and 9 neonates (64.3%) had 25OHD levels <10 ng/mL. Twenty-one neonates had hypocalcemic tetany.
The serum calcium and iCa concentrations of neonates with tetany were 4.2–8.3 mg/dL and 1.85–3.88 mg/dL, respectively. Three neonates showed symptomatic hypocalcemia with calcium levels over 7.5 mg/dL. Among the 16 neonates who underwent electroencephalography (EEG), 12 had abnormalities, which normalized after 1–2 months.
Conclusion: Formula milk feeding, PTH insufficiency and low serum vitamin D concentration are associated with the development of neonatal hypocalcemia.
Symptoms such as tetany and QT interval prolongation can develop in relatively mild hypocalcemia. Moreover, transient neonatal hypocalcemia can cause transient EEG abnormalities.
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참고문헌 (21)
참고문헌 신청
Abrams SA / 2002 / Calcium and zinc absorption from lactose-containing and lactose-free infant formulas / Am J Clin Nutr 76 : 442 ~ 446
Abrams SA. / 2010 / Calcium absorption in infants and small children: methods of determination and recent findings / Nutrients 2 : 474 ~ 480
Fomon SJ / 1993 / Nutrition of normal infants / Mosby-Year Book : 192 ~ 216
Gertner JM. / 1990 / Disorders of calcium and phosphorus homeostasis / Pediatr Clin North Am 37 : 1441 ~ 1465
Hsu SC / 2004 / Perinatal calcium metabolism: physiology and pathophysiology / Semin Neonatol 9 : 23 ~ 36
Abrams SA. / 2010 / Calcium absorption in infants and small children: methods of determination and recent findings / Nutrients 2 : 474 ~ 480
Fomon SJ / 1993 / Nutrition of normal infants / Mosby-Year Book : 192 ~ 216
Gertner JM. / 1990 / Disorders of calcium and phosphorus homeostasis / Pediatr Clin North Am 37 : 1441 ~ 1465
Hsu SC / 2004 / Perinatal calcium metabolism: physiology and pathophysiology / Semin Neonatol 9 : 23 ~ 36
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