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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제20권 제1호
- 발행연도
- 2017.1
- 수록면
- 47 - 54 (8page)
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초록· 키워드
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Purpose: Clinical symptoms associated with Clostridium difficile infection (CDI) can vary widely. Carrier state without apparent symptoms is relatively common during infancy. The objective of this study was to determine the association of C. difficile colonization with bowel habit change and the effect of C. difficile colonization treatment on restoration of normal bowel habit.Methods: Between 2006 and 2014, infants at 1 to 12 months of age with diarrhea for more than 2 weeks who did not improve with conservative care were recruited from Gachon University Gil Medical Center. Infants who were followed up for at least 7 days were included. The presence or absence of C. difficile colonization, effect of metronida-zole, and other medical records were reviewed. To determine the association between CDI and bowel habit change, logistic regression analysis was used.Results: Of a total of 126 infants, 74 (58.7%) were male patients. Of the 126 patients, 27 (21.4%) had C. difficilecolonization. Significant (p＜0.05) risk factors for C. difficile colonization included artificial milk feeding (odds ratio [OR], 4.310; 95% confidence interval [CI], 1.564-11.878), prior rotavirus vaccination (OR, 4.322; 95% CI, 1.018-18.349), and antibiotic use (OR, 4.798; 95% CI, 1.430-16.101). There was improvement in bowel habit after metronidazole therapy (OR, 0.34; 95% CI, 0.15-0.79; p＜0.05), regardless of the presence or absence of C. difficilecolonization,Conclusion: There was no significant correlation between bowel habit change and C. difficile colonization during infancy. However, metronidazole can be used as an optional method to manage functional gastrointestinal disorders.
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참고문헌 (26)
참고문헌 신청
Allen SJ / 2013 / Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inp
Almeida R / 2016 / Recurrent Clostridium difficile infection and the microbiome / J Gastroenterol 51 : 1 ~ 10
Ang L / 2014 / The establishment of the infant intestinal microbiome is not affected by rotavirus vaccination / Sci Rep 4 : 7417 ~
Benno Y / 1984 / The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants / Microbiol Immunol 28 : 975 ~ 986
Benson L / 2007 / Changing epidemiology of Clostridium difficile-associated disease in children / Infect Control Hosp Epidemiol 28 : 1233 ~ 1235
Almeida R / 2016 / Recurrent Clostridium difficile infection and the microbiome / J Gastroenterol 51 : 1 ~ 10
Ang L / 2014 / The establishment of the infant intestinal microbiome is not affected by rotavirus vaccination / Sci Rep 4 : 7417 ~
Benno Y / 1984 / The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants / Microbiol Immunol 28 : 975 ~ 986
Benson L / 2007 / Changing epidemiology of Clostridium difficile-associated disease in children / Infect Control Hosp Epidemiol 28 : 1233 ~ 1235
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