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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 575 - 580 (6page)
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In this study, we investigate whether arsenite-induced DNAdamage leads to p53-dependent premature senescence usinghuman glioblastoma cells with p53-wild type (U87MG-neo) andp53 deficient (U87MG-E6). A dose dependent relationship betweenarsenite and reduced cell growth is demonstrated, as wellas induced γH2AX foci formation in both U87MG-neo andU87MG-E6 cells at low concentrations of arsenite. Senescencewas induced by arsenite with senescence-associated β-galactosidasestaining. Dimethyl- and trimethyl-lysine 9 of histoneH3 (H3DMK9 and H3TMK9) foci formation was accompaniedby p21 accumulation only in U87MG-neo but not inU87MG-E6 cells. This suggests that arsenite induces prematuresenescence as a result of DNA damage with heterochromatinforming through a p53/p21 dependent pathway. p21 and p53siRNA consistently decreased H3TMK9 foci formation in U87MG-neo but not in U87MG-E6 cells after arsenite treatment.
Taken together, arsenite reduces cell growth independently ofp53 and induces premature senescence via p53/p21-dependentpathway following DNA damage.
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참고문헌 (24)
참고문헌 신청
Au, W. Y. / 2006 / Elemental arsenic entered the cerebrospinal fluid during oral arsenic trioxide treatment of meningeal relapse of acute promyelocytic leukemia / Blood 107
Brandes, A. A. / 2008 / Glioblastoma in adults / Crit. Rev. Oncol. Hematol 67 : 139 ~ 152
Cui, X. / 2006 / Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells / Hum. Pathol 37 : 298 ~ 311
Cui, X. / 2008 / Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer / Curr. Med. Chem 15 : 2293 ~ 2304
Dimri, G. P. / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc. Natl. Acad. Sci. U.S.A 92 : 9363 ~ 9367
Brandes, A. A. / 2008 / Glioblastoma in adults / Crit. Rev. Oncol. Hematol 67 : 139 ~ 152
Cui, X. / 2006 / Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells / Hum. Pathol 37 : 298 ~ 311
Cui, X. / 2008 / Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer / Curr. Med. Chem 15 : 2293 ~ 2304
Dimri, G. P. / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc. Natl. Acad. Sci. U.S.A 92 : 9363 ~ 9367
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