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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 283 - 288 (6page)
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We found that resveratrol enhances interferon (IFN)--induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3 (GSK-3) activity. In addition, we found that resveratrol regulates naïve CD8+ T-cell polarization by modulating GSK-3 activity in IFN--stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8+ T-cells in the in vivo tumor environment.
Taken together, resveratrol upregulates IFN--induced TTS expression in a GSK-3-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation.
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참고문헌 (25)
참고문헌 신청
Aggarwal BB / 2004 / Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies / Anticancer Res 24 : 2783 ~ 2840
Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
Baur JA / 2006 / Therapeutic potential of resveratrol:the in vivo evidence / Nat Rev Drug Discov 5 : 493 ~ 506
Boasso A / 2005 / Regulation of indoleamine 2, 3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells / Blood 105 : 1574 ~ 1581
Doble BW / 2003 / GSK-3 : tricks of the trade for a multi-tasking kinase / J Cell Sci 116 : 1175 ~ 1186
Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
Baur JA / 2006 / Therapeutic potential of resveratrol:the in vivo evidence / Nat Rev Drug Discov 5 : 493 ~ 506
Boasso A / 2005 / Regulation of indoleamine 2, 3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells / Blood 105 : 1574 ~ 1581
Doble BW / 2003 / GSK-3 : tricks of the trade for a multi-tasking kinase / J Cell Sci 116 : 1175 ~ 1186
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