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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 14 - 20 (7page)
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Biomedical research involving nanoparticles has produced useful products with medical applications. However, the potential toxicity of nanoparticles in biofluids, cells, tissues, and organisms is a major challenge. The '-omics' analyses provide molecular profiles of multifactorial biological systems instead of focusing on a single molecule. The 'omics' approaches are necessary to evaluate nanotoxicity because classical methods for the detection of nanotoxicity have limited ability in detecting miniscule variations within a cell and do not accurately reflect the actual levels of nanotoxicity. In addition, the 'omics' approaches allow analyses of in-depth changes and compensate for the differences associated with high-throughput technologies between actual nanotoxicity and results from traditional cytotoxic evaluations. However, compared with a single omics approach, integrated omics provides precise and sensitive information by integrating complex biological conditions. Thus, these technologies contribute to extended safety evaluations of nanotoxicity and allow the accurate diagnoses of diseases far earlier than was once possible in the nanotechnology era. Here, we review a novel approach for evaluating nanotoxicity by integrating metabolomics with metabolomic profiling and transcriptomics, which is termed "metabotranscriptomics".
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참고문헌 (76)
참고문헌 신청
Stark WJ / 2011 / Nanoparticles in biological systems / Angew Chem Int Ed Engl 50:1242~1258
Havel H / 2016 / Nanomedicines: From Bench to Bedside and Beyond / AAPS J 18:1373~1378
Yang Y / 2016 / Advances in silica based nanoparticles for targeted cancer therapy / Nanomedicine 12:317~332
Deng R / 2017 / Nanoparticle interactions with co-existing contaminants: Joint toxicity, bioaccumulation and risk / Nanotoxicology :1~56
Vayssieres L / 1998 / Size Tailoring of Magnetite Particles Formed by Aqueous Precipitation: An Example of Thermodynamic Stability of Nanometric Oxide Particles / J Colloid Interface Sci 205:205~212
Havel H / 2016 / Nanomedicines: From Bench to Bedside and Beyond / AAPS J 18:1373~1378
Yang Y / 2016 / Advances in silica based nanoparticles for targeted cancer therapy / Nanomedicine 12:317~332
Deng R / 2017 / Nanoparticle interactions with co-existing contaminants: Joint toxicity, bioaccumulation and risk / Nanotoxicology :1~56
Vayssieres L / 1998 / Size Tailoring of Magnetite Particles Formed by Aqueous Precipitation: An Example of Thermodynamic Stability of Nanometric Oxide Particles / J Colloid Interface Sci 205:205~212
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